Résumé
La fibromyalgie se présente à l’heure actuelle comme une situation d’hyperalgésie qui semble répondre à diverses substances agissant sur les voies sérotoninergiques, les récepteurs NMDA ou les canaux calciques. La préparation mentale et physique des patients reste la pierre angulaire du traitement.
Abstract
Today, fibromyalgia is characterized as a syndrome of hyperalgesia that responds to a variety of therapeutic drugs acting either on serotoninergic pathways, NMDA receptors, or calcium channels. However, despite advances in drug therapy development, the most effective treatment for fibromyalgia remains mental and physical training.
This is a preview of subscription content, log in via an institution to check access.
Références
Bennett RM, Clarck SC, Walkzyk J (1998) A randomized, double-blind, placebo-controlled study of growth hormone in the treatment of fibromyalgia. Am J Med 104(3): 227–231
Lucas HJ, Brauch CM, Settas L, Theoharides TC (2006) Fibromyalgia-new concepts of pathogenesis and treatment. Int J Immunopathol Pharmacol 19(1): 5–10
Bazzichi L, Giannaccini G, Betti L, et al. (2006) Alteration of serotonin transporter density and activity in fibromyalgia. Arthritis Research & Therapy 8: R99
Miller LJ, Kubes KL (2002) Serotonergic agents in the treatment of fibromyalgia syndrome. Ann Pharmacother 36(4): 707–712
Arnold LM, Hess EV, Hudson JI, et al. (2002) A randomized, placebo-controlled, double-blind, flexibledose study of fluoxetine in the treatment of women with fibromyalgia. Am J Med 112(3): 191–197
Gendreau RM, Thorn MD, Gendreau JF, et al. (2005) Efficacy of milnacipran in patients with fibromyalgia. J Rheumatol 32(10): 1975–1985
Samborski W, Lezanska-Szpera M, Rybakowski JK (2004) Effects of antidepressant mirtazapine on fibromyalgia symptoms. Rocz Akad Med Byalimst 49: 265–269
Sayar K, Aksu G, Ak I, Tosun M (2003) Venlafaxine treatment of fibromyalgia. Ann Pharmacother 37(11): 1561–1565
Arnold LM, Rosen A, Pritchett YL, et al. (2005) A randomized, double-blind, placebo-controlled trial of duloxetine in the treatment of women with fibromyalgia with or without major depressive disorder. Pain 119(1–3): 5–15
Bennett RM, Kamin M, Karim R, Rosenthal N (2003) Tramadol and acetaminophen combination tablets in the treatment of fibromyalgia pain: a double-blind, randomized, placebo-controlled study. Am J Med 114(7): 537–545
Biasi G, Manca S, Manganelli S, Marcolongo R (1998) Tramadol in the fibromyalgia syndrome: a controlled clinical trial versus placebo. Int J Clin Pharmacol Res 18(1): 13–19
Spath M, Stratz T, Farber L, et al. (2004) Treatment of fibromyalgia with tropisetron-dose and efficacy correlations. Scan J Rheumatol Suppl (119): 63–66
Stratz T, Fiebich B, Haus U, Muller W (2004) Influence of tropisetron on the serum substance P levels in fibromyalgia patients. Scan J Rheumatol Suppl (119): 41–43
Cohen SP, Verdolin MH, Chang AS, et al. (2006) The intravenous ketamine test predicts subsequent response to an oral dextromethorphan treatment regimen in fibromyalgia patients. J Pain 7(6): 391–398
Crofford LJ, Rowbotham MC, Mease PJ, et al. (2005) Pregabalin for the treatment of fibromyalgia syndrome: results of a randomized, double-blind, placebo-controlled trial. Arthritis Rheum 52(4): 1264–1273
Author information
Authors and Affiliations
Corresponding author
About this article
Cite this article
Bouju, P. Traitements médicamenteux de la fibromyalgie. Lett Med Phys Readapt 23, 90–92 (2007). https://doi.org/10.1007/s11659-007-0063-x
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11659-007-0063-x