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Association of high-density lipoprotein, triglycerides, and homocysteine with bone mineral density in young Indian tribal women

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Abstract

Summary

This study investigated association between lipids and homocysteine (Hcy) with bone mineral density (BMD) in young women as opposed to previous studies on elderly women. HDL, triglyceride, and Hcy are significantly associated with BMD in young women and tobacco and alcohol consumption have no effect on this association.

Purpose

The present study investigates whether the association of serum lipids and homocysteine (Hcy) with bone mineral density (BMD) reported mostly in elderly population can be generalized to young or premenopausal women, consequently suggesting screening of young women with low BMD for dyslipidemia or any cardiovascular events and vice versa.

Methods

Women (n = 293, aged 20–47 years) from Northeast India belonging to Tibeto-Burman origin were enrolled. Information about their physical and clinical attributes were collected by a structured questionnaire. Their BMDs at lumbar spine and femur were measured by dual-energy X-ray absorptiometry (DXA) and sera were profiled for lipid parameters and Hcy by auto-analyzer and ELISA, respectively. Women consuming tobacco and/or alcohol were grouped as consumers and others as non-consumers for the analysis.

Results

Positive correlation of BMD with HDL (spine and femur r = 0.38, p < 0.0001) and triglyceride (spine r = 0.534, p < 0.0001; femur r = 0.423, p < 0.0001) was observed, whereas Hcy correlated negatively with BMD (spine r = − 0.189, p = 0.0026; femur r = − 0.273, p < 0.0001). LDL showed a weak negative correlation with BMD (spine r = − 0.128, p = 0.0283; femur r = − 0.199, p = 0.0006). However, after adjusting for age, BMI, and consumption, HDL, triglyceride, and Hcy continued to show significant correlation with BMD at both the sites. Logistic regression analyses indicated that HDL, triglyceride, and Hcy were significant predictors of osteopenia and osteoporosis in our study cohort; however, consumption did not contribute to its prediction.

Conclusion

Low levels of HDL and triglyceride and high levels of Hcy are significantly associated with osteopenia and osteoporosis in young Northeast Indian women.

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Acknowledgements

The authors acknowledge Dr. S. D. Mahale, Director, and Dr. S. D. Kholkute, Ex-Director ICMR-NIRRH, Mumbai, for their constant support throughout the study. The authors are also thankful to Ms. Liza Debbarma, Ms. Monika Das, and Ms. Manisha Roy for their help in recruitment of participants and measurement of biochemical parameters.

Funding

The authors thank the Department of Biotechnology-Northeast (DBT-NE) Twinning Program for funding the study and for the research fellowship awarded to Ms. Rucha Saoji.

Author information

Authors and Affiliations

  1. ICMR-National Institute for Research in Reproductive Health, J. M. Street, Parel, Mumbai, Maharashtra, 400012, India

    Rucha Saoji, Meena Desai, Geetanjali Sachdeva & M. Ikram Khatkhatay

  2. Agartala Government Medical College, Agartala, Tripura, 799006, India

    Rajat Subra Das & Tapan Kumar Das

  3. Airport Health Organisation, Ministry of Health & Family Welfare (GOI), Andheri, Mumbai, Maharashtra, 400099, India

    Achhelal Pasi

Authors
  1. Rucha Saoji
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  2. Rajat Subra Das
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  3. Meena Desai
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  4. Achhelal Pasi
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  5. Geetanjali Sachdeva
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  6. Tapan Kumar Das
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  7. M. Ikram Khatkhatay
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Corresponding author

Correspondence to M. Ikram Khatkhatay.

Ethics declarations

The study protocol was approved by the Clinical Ethics Committee of Agartala Government Medical College (AGMC), Agartala, and ICMR-National Institute for Research in Reproductive Health Ethics Committee for Clinical Studies, Mumbai (252/2014). Informed consent was obtained from all participants included in the study before their enrolment.

Grant supporters

Department of Biotechnology, Government of India

Conflicts of interest

None.

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Saoji, R., Das, R.S., Desai, M. et al. Association of high-density lipoprotein, triglycerides, and homocysteine with bone mineral density in young Indian tribal women. Arch Osteoporos 13, 108 (2018). https://doi.org/10.1007/s11657-018-0525-6

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  • DOI: https://doi.org/10.1007/s11657-018-0525-6

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