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Bone mineral density and lipid profiles in older adults: a nationwide cross-sectional study

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Abstract

Summary

It has been hypothesized that lipid profiles are associated with bone mineral density (BMD), but previous results have been controversial. In this study, serum triglycerides showed a significant inverse association with BMD, and the relationship is thought to correlate with vitamin D status among older adults.

Introduction

The purpose of this study was to investigate the relationship between lipid profiles and bone mineral density (BMD) in older adults using data from the Korean National Health and Nutrition Examination Survey (KNHANES).

Methods

We enrolled men older than 50 years and postmenopausal women who participated in the KNHANES 2008–2011. Subjects with liver cirrhosis, thyroid disease, or renal dysfunction and those receiving treatment for hyperlipidemia or osteoporosis were excluded.

Results

A total of 4323 subjects (2286 men and 2037 women) was analyzed. The prevalence of osteoporosis was 8.7% in men older than 50 years and 38.4% in postmenopausal women. Osteopenia and osteoporosis groups were generally older and tended to have a lower body mass index compared to the normal group (p for trend < 0.001). The correlation between each lipid profile and BMD was analyzed in the linear model adjusted for age and body mass index. Total cholesterol and high-density lipoprotein cholesterol showed a negative correlation with BMD in the total population, but there was no significant correlation when analyzed separately for men and women. Triglycerides had a negative association with whole-body BMD in both men and women (p < 0.05). The adjusted odds ratio of logarithmic triglyceride level for osteoporosis was 2.50 (95% confidence interval 1.13–5.51) in women older than 65 years.

Conclusion

Serum triglycerides showed a significant inverse association with BMD, and the relationship is thought to correlate with vitamin D status among older adults.

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Acknowledgements

Statistical consultation was supported by the Department of Biostatistics of the Catholic Research Coordinating Center.

Funding

This research was supported by a grant from the Institute of Clinical Medicine Research in Yeouido St. Mary’s Hospital, The Catholic University of Korea.

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Authors and Affiliations

  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Yeouido St. Mary᾽s Hospital, College of Medicine, The Catholic University of Korea, 63-ro, Yeongdeungpo-gu, Seoul, South Korea

    Jinyoung Kim, Mee Kyoung Kim, Hyuk-Sang Kwon, Ki-Ho Song & Ki-Hyun Baek

  2. Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary᾽s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Jeonghoon Ha

  3. Division of Endocrinology and Metabolism, Department of Internal Medicine, Uijeongbu St. Mary᾽s Hospital, College of Medicine, The Catholic University of Korea, Uijeongbu, Gyeonggi-do, South Korea

    Chaiho Jeong

  4. Division of Endocrinology and Metabolism, Department of Internal Medicine, Eunpyeong St. Mary᾽s Hospital, College of Medicine, The Catholic University of Korea, Seoul, South Korea

    Jeongmin Lee

  5. Division of General Internal Medicine, Department of Internal Medicine, Seoul National University Bundang Hospital, Seoul National University College of Medicine, Seoul, Gyeonggi-do, South Korea

    Yejee Lim

  6. Division of Endocrinology and Metabolism, Department of Internal Medicine, Incheon St. Mary᾽s Hospital, College of Medicine, The Catholic University of Korea, Incheon, South Korea

    Kwanhoon Jo

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Contributions

Conception or design: J. K., K. H. B. Acquisition, analysis, or interpretation of data: J. K., J. H., C. J., J. L., Y. L., K. J., M. K. K., H. S. K., K. H. S., K. H. B. Drafting or revising the work: J. K. Final approval of the manuscript: J. K., J. H., C. J., J. L., Y. L., K. J., M. K. K., H. S. K., K. H. S., K. H. B.

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Correspondence to Ki-Hyun Baek.

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Kim, J., Ha, J., Jeong, C. et al. Bone mineral density and lipid profiles in older adults: a nationwide cross-sectional study. Osteoporos Int 34, 119–128 (2023). https://doi.org/10.1007/s00198-022-06571-z

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