Abstract
The human immune system represents a dynamic multiscale system with high complexity in biology. Humoral immunity, as the main branch of adaptive immunity, is characterized by differentiated stages of the B lymphocytes, producing the final product of antibodies that has a diversity of the tuning mechanisms within genetic and epigenetic levels in confrontation with environmental exposures. Disorders because of disturbed humoral immunity are linked with dysregulation of feedback-regulated signaling and the dynamic of immune components that determine the overall response. Food products, mainly herbal components have a significant role in tailoring the immune system micro-ecosystem which can diversify the adaptive nature of humoral immunity. Herein, we review the current evidence-based approaches for the impact of medicinal herbs on humoral immunity signaling and antibody production with a focus on immunotherapeutic applications.
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FN and HA contributed to the conception and design of the study, and analysis and interpretation of data. MAZ and MY contributed to acquisition of data. HA and MAZ drafted the article. All authors revised it critically for important intellectual content and approved the final version to be submitted.
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Nejatbakhsh, F., Zareian, M.A., Yaseliani, M. et al. Evidence-Based Immunotherapeutic Effects of Herbal Compounds on Humoral Immunity: Ancient and New Approaches. Chin. J. Integr. Med. 27, 313–320 (2021). https://doi.org/10.1007/s11655-021-3332-7
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DOI: https://doi.org/10.1007/s11655-021-3332-7