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Effect of Weikang Capsule (胃康胶囊) on Aspirin-Related Gastric and Small Intestinal Mucosal Injury

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Abstract

Objective

To investigate the effects of Weikang Capsule (胃康胶囊, WKC) on aspirin-related gastric and small intestinal mucosal injury by magnetically controlled capsule endoscopy (MCCE).

Methods

Patients taking enteric-coated aspirin aged 40–75 years were enrolled in Beijing Anzhen Hospital, Capital Medical University from January 2019 to December 2019. The patients continued taking aspirin Tablet (100 mg per day) and underwent MCCE before and after 1-month combined treatment with WKC (0.9 g per time orally, 3 times per day). The gastrointestinal symptom score, gastric Lanza score, the duodenal, jejunal and ileal mucosal injury scores were used to evaluate the gastrointestinal injury before and after treatment. Adverse events including nausea, vomiting, abdominal pain, abdominal distension, abdominal discomfort, dizziness, or headache during MCCE and combined treatment were observed and recorded.

Results

Twenty-two patients (male/female, 13/9) taking enteric-coated aspirin aged 59.5 ± 11.3 years with a duration of aspirin use of 28.0 (1.0, 48.0) months were recruited. Compared with pre-treatment, the gastrointestinal symptom rating scale scores, gastric Lanza scores, and duodenal mucosal injury scores were significantly reduced after 1-month WKC treatment (P<0.05), and jejunal and ileal mucosal injury scores showed no obvious change. No adverse events occurred during the trial.

Conclusions

WKC can alleviate gastrointestinal symptoms, as well as gastric and duodenal mucosal injuries, in patients taking enteric-coated aspirin; it does not aggravate jejunal or ileal mucosal injury, which may be an effective alternative for these patients (Clinical trial registry No. ChiCTR1900025451).

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Acknowledgments

We thank all of the subjects for their participation in this study.

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Authors and Affiliations

  1. Department of Gastroenterology, Beijing Anzhen Hospital, Capital Medical University, Beijing, 100029, China

    Lin Du, Feng Gao & Jie Zhang

Authors
  1. Lin Du
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  2. Feng Gao
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  3. Jie Zhang
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Corresponding author

Correspondence to Jie Zhang.

Additional information

Supported by Beijing Chinese Medicine Science and Technology Development Fund (No. JJ2018–02)

Conflict of Interest

The authors declare that they have no competing interests.

Author Contributions

Du L was responsible for drafting the manuscript and interpreting the data. Gao F was responsible for data collection and analyses. Zhang J was responsible for the study design and revision of the manuscript.

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Du, L., Gao, F. & Zhang, J. Effect of Weikang Capsule (胃康胶囊) on Aspirin-Related Gastric and Small Intestinal Mucosal Injury. Chin. J. Integr. Med. 27, 621–625 (2021). https://doi.org/10.1007/s11655-021-3300-2

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  • DOI: https://doi.org/10.1007/s11655-021-3300-2

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