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Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke

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Abstract

Objective

To observe the effects and safety of Tongyan Spray (通咽喷雾剂) on the range and time of hyoid motion in patients with ischemic post-stroke dysphagia.

Methods

Seventy-two patients with ischemic post-stroke dysphagia were selected and randomly assigned to a treatment group (36 cases) and a control group (36 cases) by a random number table from January 2013 to October 2014. All patients swallowed 4 kinds of barium meals with different traits respectively, and each patient underwent video fluoroscopy (VF) examination twice. In the treatment group, Tongyan Spray was sprayed to the pharynx on both sides and the middle part once respectively. The spray was applied 30 min before the second examination. Purified water at room temperature was used as placebo in the control group. The changes in the range and time of hyoid motion in both groups were observed before and after treatment.

Results

Six patients dropped out in each group, and 60 patients completed the study and were included in the final analysis. Significant improvement was observed in the range of superior hyoid excursion distance and the time of hyoid motion in the treatment group compared with the control group (P<0.05). There were no obvious adverse reactions observed in oral mucosa in both groups during the whole study.

Conclusion

Tongyan Spray was an effective and safe medicine for improving swallowing function in patients with ischemic post-stroke dysphagia.

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Authors and Affiliations

  1. Department of Encephalopathy, Beijing Hospital of Integrated Traditional Chinese and Western Medicine, Beijing, 100039, China

    Wen-jie Hao, Xiao-lei Wu, Wen-yan Zhang & Xue-gong Feng

  2. Department of Neurology, China Rehabilitation Research Center, Beijing, 100068, China

    Bing-jie Li

  3. Department of Radiology, China Rehabilitation Research Center, Beijing, 100068, China

    Zhen-bo Chen & Han Yao

  4. The 3rd Department of Neurorehabilitation, China Rehabilitation Research Center, Beijing, 100068, China

    Xin Zhang

Authors
  1. Wen-jie Hao
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  2. Bing-jie Li
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  3. Xiao-lei Wu
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  4. Zhen-bo Chen
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  5. Xin Zhang
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  6. Han Yao
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  7. Wen-yan Zhang
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  8. Xue-gong Feng
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Contributions

Feng XG designed the experiments and presided over integral experiment process; Hao WJ analyzed the data and wrote the paper; Li BJ conducted the experiments; Chen ZB, Zhang X and Yao H supervised the experiments; Wu XL collected cases; Zhang WY assisted in data analysis. All the authors read, revised and approved the final manuscript.

Corresponding author

Correspondence to Xue-gong Feng.

Additional information

Supported by the National Natural Science Foundation of China (No. 81273705)

Conflict of Interest

The authors declare that there is no conflict of interest.

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Hao, Wj., Li, Bj., Wu, Xl. et al. Effect and Safety of Tongyan Spray (通咽喷雾剂) on Hyoid Motion in Patients with Dysphagia after Ischemic Stroke. Chin. J. Integr. Med. 27, 369–374 (2021). https://doi.org/10.1007/s11655-020-3325-y

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  • DOI: https://doi.org/10.1007/s11655-020-3325-y

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