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Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis

Chinese Journal of Integrative Medicine volume 27, pages 286–290 (2021)Cite this article

Abstract

Objective

To evaluate the effect and safety of cinnamaldehyde on immunosuppressed mice with invasive pulmonary candidiasis.

Methods

An immunosuppressed BALB/c mouse model was established by intraperitoneal administration of cyclophosphamide (200 mg/kg) once daily for 2 days. The immunosuppressed mouse with invasive pulmonary candidiasis model was further established by nasal perfusion of Candida albicans suspension. In the cinnamaldehyde treatment group, immunosuppressed mice with invasive pulmonary candidiasis were orally given cinnamaldehyde 240 mg/(kg·d) for 14 consecutive days. Fluconazole and 0.9% saline were used as the positive and negative controls, respectively. The mice in the cinnamaldehyde safety evaluation group were orally administered cinnamaldehyde 480 mg/(kg·d) for 42 days to observe the safety of the drug. Microscopic identification, fungal culture, histopathological examination, and (1,3)-beta-D-glucans detection were conducted to analyze the effect of cinnamaldehyde on C. albicans.

Results

The fungal clearance rate in the cinnamaldehyde treatment group was higher than that in the fluconazole control group (80.00% vs. 56.67%, P<0.05). The level of (1,3)-β-D-glucan in the cinnamaldehyde treatment group was lower than that in the fluconazole positive control group (1160.62 ±89.65 pg/mL vs. 4285.87 ± 215.62 pg/mL, P<0.05). The survival rate of mice in the cinnamaldehyde safety evaluation group was 100%, and no significant pathological changes of kidney, lung and liver were observed.

Conclusions

Cinnamaldehyde was effective and safe in treating immunosuppressed BALB/c mice with invasive pulmonary candidiasis. It would be a potentially novel drug for anti-candidiasis infection.

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Author information

Affiliations

  1. Department of Dermatology, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

    Jie-hua Deng

  2. Clinical Lab, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

    Ji-hong Li

  3. Department of Pharmacy, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

    Yi-le Zhao

  4. Department of Scientific Research, the Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China

    Gang-sheng Wang

Authors
  1. Jie-hua Deng
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  2. Ji-hong Li
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  3. Yi-le Zhao
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  4. Gang-sheng Wang
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Contributions

Wang GS conceived and supervised the study; Li JH and Deng JH designed the experiments; Li JH, Deng JH and Zhao YL performed the experiments; Wang GS analyzed the data and wrote the manuscript. All authors listed have read the complete manuscript and have approved submission of the paper.

Corresponding author

Correspondence to Gang-sheng Wang.

Ethics declarations

There was no conflict of interest.

Additional information

Supported by the Natural Science Foundation of Hebei Province (No. H2013206316)

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Deng, Jh., Li, Jh., Zhao, Yl. et al. Effect and Safety of Cinnamaldehyde on Immunosuppressed Mice with Invasive Pulmonary Candidiasis. Chin. J. Integr. Med. 27, 286–290 (2021). https://doi.org/10.1007/s11655-020-3075-x

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  • DOI: https://doi.org/10.1007/s11655-020-3075-x

Keywords

  • cinnamaldehyde
  • Candida albicans
  • invasive pulmonary infection
  • Chinese medicine
  • safety