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Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer’s Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency

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Abstract

Objective

To observe the intervention effects of Tiaobu Xinshen Recipe (调补心肾方, TXR) on patients with mild cognitive impairment caused by Alzheimer’s disease (MCI-AD).

Methods

Totally 88 MCI-AD patients with syndrome of Xin (Heart) and Shen (Kidney) deficiency were assigned to the experimental group (47 cases, treated with TXR) and the control group (41 cases, treated with donepezil hydrochloride) using a random number table. Final recruited qualified patients were 44 cases in the experimental group and 39 cases in the control group. The therapeutic course was 12 weeks. Neuropsychological scales [mini mental state examination (MMSE) and Montreal cognitive assessment (MoCA)], and Chinese medicine (CM) dementia syndromes scales were performed in all patients, and results were compared between groups or intra-group before and after treatment.

Results

MMSE and MoCA scores of the two groups were increased after treatment compared with those before treatment (P<0.05). But there was no statistical difference in MMSE or MOCA scores after treatment between the two groups (P>0.05). CM dementia syndrome score was significantly decreased after treatment in the experimental group compared with the control group (P<0.01). Visual spatial and executive function scores and delayed recall scores of the two groups were increased compared with those before treatment (P<0.01).

Conclusion

TXR could effectively improve cognitive impairment of MCI-AD patients with syndrome of Xin and Shen deficiency.

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Acknowledgment

We are grateful to all the participants and staffs in the trial.

Author information

Authors and Affiliations

  1. Department of Traditional Chinese Medicine, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, 350001, China

    Zhi-ying Lin & Guan-yi Zheng

  2. Department of Neurology, The Affiliated Union Hospital of Fujian Medical University, Fuzhou, 350001, China

    Tian-wen Huang

  3. Key Laboratory of Traditional Chinese Medicine for the Treatment of Brain Dysfunction, Fujian Academy of Traditional Chinese Medicine, Fuzhou, 350001, China

    Jun-shang Huang

Authors
  1. Zhi-ying Lin
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  2. Tian-wen Huang
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  3. Jun-shang Huang
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  4. Guan-yi Zheng
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Contributions

Lin ZY designed the research and analyzed the data. Lin ZY and Huang TW drafted the manuscript. Huang JS managed and coordinated the study. Zheng GY assisted with subject recruitment and supervised training sessions. All authors have read and approved the final version of the manuscript.

Corresponding author

Correspondence to Zhi-ying Lin.

Additional information

Conflict of Interest

All the authors declare that they have no competing interests.

Supported by Fujian Provincial Research Project of Traditional Chinese Medicine (No. wzkf201309)

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Lin, Zy., Huang, Tw., Huang, Js. et al. Tiaobu Xinshen Recipe (调补心肾方) Improved Mild Cognitive Impairment of Alzheimer’s Disease Patients with Xin (Heart) and Shen (Kidney) Deficiency. Chin. J. Integr. Med. 26, 54–58 (2020). https://doi.org/10.1007/s11655-019-3073-z

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  • DOI: https://doi.org/10.1007/s11655-019-3073-z

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