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Efficacy and Safety Evaluation of Taohong Siwu Decoction (桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials

  • Evidence-Based Integrative Medicine
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Abstract

Objective

To assess the efficacy and safety of Taohong Siwu Decoction (桃红四物汤, TSD), a Chinese herbal compound prescription, in patients with angina pectoris (AP).

Methods

Randomized clinical trials (RCTs) comparing TSD plus conventional treatment (CT) with CT plus placebo or CT only in the patients with AP were searched in PubMed, Cochrane Library, Excerpta Medica Database, Chinese National Knowledge Infrastructure, Chinese Biomedical Literature Database, Wanfang Database, Chinese Scientific Journal Database, Chinese Clinical Trial Registry and International Clinical Trial Registry from their inception to March 2017. The primary outcomes include a composite event of death, acute myocardial infarction (AMI), and target vessel revascularization. The secondary outcomes include angina symptom, electrocardiogram (ECG) improvement and serum high-sensitivity C-reactive protein (hs-CRP), endothelin-1 (ET-1), triglycerides (TG), total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) levels. The methodological quality of included studies and extracted available data were assessed. RevMan 5.3 software was used to conduct statistical analysis. The relative risk (RR) and standardized mean difference (SMD) with 95% confidence interval (CI) was calculated. A funnel plot was used to evaluate the publication bias.

Results

Among 204 studies identified in the literature search, 12 trials including 959 patients with AP met the inclusion criteria. No studies reported the primary outcome including death, AMI and target vessel revascularization. TSD combined with CT showed significant improvement in relieving angina symptom [RR=3.70, 95% CI (2.42, 5.67)] and ECG [RR=3.20, 95% CI (2.20, 4.65)] compared with CT alone. TSD combined with CT reduced the serum hs-CRP, TG, TC and LDL-C levels compared with CT alone. No serious adverse events were reported in TSD combined with CT.

Conclusions

TSD combined with CT has a potential benefit on relieving AP without significant adverse events. However, the efficacy on the cardiovascular events needs to be assessed by more rigorously-designed, largescale, and multi-center RCTs in future.

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References

  1. GBD 2013 Mortality and Causes of Death Collaborators. Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet 2015;385:117–171.

    Article  Google Scholar 

  2. Wang W, Hu SS, Kong LZ, Gao RL, Zhu ML, Wang WY, et al. Summary of report on cardiovascular diseases in China, 2012. Biomed Environ Sci 2014;27:552–558.

    PubMed  Google Scholar 

  3. Task Force Members. 2013 ESC guidelines on the management of stable coronary artery disease: the task force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J 2013;34:2949–3003.

    Article  Google Scholar 

  4. Parikh R, Kadowitz PJ. Angina pectoris: current therapy and future treatment options. Expert Rev Cardiovasc Ther 2014;12:175–186.

    Article  CAS  Google Scholar 

  5. White WB, Johnson MF, Anders RJ, Elliott WJ, Black HR. Safety of controlled-onset extended-release verapamil in middle-aged and older patients with hypertension and coronary artery disease. Am Heart J 2001;142:1010–1015.

    Article  CAS  Google Scholar 

  6. Dixit D, Kimborowicz K. Pharmacologic management of chronic stable angina. J Am Acad Phys 2015;28.

    Google Scholar 

  7. Rui YR. Taohong Siwu Decoction combined with venomin antiembolic enzyme in treating unstable angina pectoris. Liaoning J Tradit Chin Med (Chin) 2002;29:674–675.

    Google Scholar 

  8. Liu LJ. Modified Taohong Siwu Decoction on 64 cases of stable angina pectoris. Tianjin J Tradit Chin Med (Chin) 2006;23:434.

    Google Scholar 

  9. Deng RC. Clinical observation on treatment of angina pectoris with integrated Chinese and Western medicine. J Clin Exp Med (Chin) 2010;9:787–788.

    Google Scholar 

  10. Xiao ZQ. Curative effect in treating angina pectoris with integrative Chinese and Western medicine. Strait Pharm J (Chin) 2007;19:101–102.

    CAS  Google Scholar 

  11. Wang XB. Clinical observation of integrative Chinese and Western medicine in treating 46 cases with angina pectoris. Chin Pract Med (Chin) 2013;8:182.

    Google Scholar 

  12. He YY, Zhu ZX, Wang HQ. The effect observation and nursing of Taohong Siwu Decoction in treating 30 cases with unstable angina pectoris. Chin Pharm (Chin) 2011;20:76–77.

    CAS  Google Scholar 

  13. Jing XM, Wang XH. Taohong Siwu Decoction combined with sodium ozagrel injection in treating unstable angina pectoris. Hebei J Tradit Chin Med (Chin) 2009;31:1193–1203.

    Google Scholar 

  14. Chen B. The effect of Taohong Siwu Decoction on vasospastic angina with qi stagnation and blood stasis and its influence on ET-1[D]. Heilongjiang University of Chinese Medicine 2013.

    Google Scholar 

  15. Yu SF. Clinical research on Taohong Siwu Decoction combined with conventional Western medicine for treating angina pectoris in coronary heart disease. Henan Tradit Chin Med (Chin) 2015;35:1527–1529.

    Google Scholar 

  16. Li X. Chinese and Western medicine combination therapy clinical observation of 40 cases of coronary heart disease. Chin J Ethnomed Ethnopharmacy (Chin) 2015;24:110–111.

    CAS  Google Scholar 

  17. Zheng GY, Wang JX, Li JG. The effect observation of Taohong Siwu Decoction combined with Huangqi in treating unstable angina pectoris. Chin J Tradit Med Sci Tech (Chin) 2010;17:357–358.

    Google Scholar 

  18. Liu ZQ, Yin DK, Han L, Li BK, Peng DY. Protective effect of medicated serum prepared with Taohong Siwu Decoction on hydrogen peroxide-induced human umbilical vein endothelial cells. China J Chin Meter Medica (Chin) 2013;38:402–406.

    Google Scholar 

  19. Bourassa MG, Alderman EL, Bertrand M, de la Fuente L, Gratsianski A, Kaltenbach M, et al. Report of the joint meeting of the International Society and Federation of Cardiology and the World Health Organization Task Force on Coronary Angioplasty. Arch Mal Coeur Vaiss 1989;82:2053–2063.

    CAS  PubMed  Google Scholar 

  20. Chinese Society of Cardiology of Chinese Medical Association; Editorial Board of Chinese Journal of Cardiology. Guideline for diagnosis and treatment of patients with unstable angina and non-ST-segment elevation myocardial infarction. Chin J Cardiol (Chin) 2007;35:295–304.

    Google Scholar 

  21. Chinese Society of Cardiology of Chinese Medical Association; Editorial Board of Chinese Journal of Cardiology. Chinese guidelines for prevention of cardiovascular diseases. Chin J Cardiol (Chin) 2011;39:3–22.

    Google Scholar 

  22. Higgins JP, Green S. Cochrane handbook for systematic reviews of interventions: Version 5.1.0. The Cochrane Collaboration 2011. Available at: www.cochrane-handbook.org.

    Google Scholar 

  23. Chu LX, Sun MZ, Zhang W, Luo XY, Chen L, Ma LH, et al. The effect of modified Taohong Siwu Decoction on hs-CRP of patients with coronary heart disease. Nei Mongol J Tradit Chin Med (Chin) 2014;3:36–37.

    Google Scholar 

  24. Wang JF, Zhang SZ, Zhang NY, Wu ZY, Feng JY, Ying LP, et al. Laparoscopic gastrectomy versus open gastrectomy for elderly patients with gastric cancer: a systematic review and meta-analysis. World J Surg Oncol 2016;14:90.

    Article  Google Scholar 

  25. Yang X, Xiong X, Yang G, Wang J. Chinese patent medicine Xuefu Zhuyu Capsule for the treatment of unstable angina pectoris: A systematic review of randomized controlled trials. Complement Ther Med 2014;22:391–399.

    Article  Google Scholar 

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Authors and Affiliations

  1. Department of Pathophysiology, Chinese PLA General Hospital, Beijing, 100853, China

    Tian-qi Tao, Hui-min Mao, Lei Xia & Xiu-hua Liu

  2. Department of Nephrology, Guang’anmen Hospital, Beijing, 100053, China

    Hui-min Mao

Authors
  1. Tian-qi Tao
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  2. Hui-min Mao
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  3. Lei Xia
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  4. Xiu-hua Liu
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Corresponding author

Correspondence to Xiu-hua Liu.

Additional information

Supported by National Basic Research Program of China (973 Program, No. 2015CB554402, 2015CB554405) and National Natural Science Foundation of China (No. 31771287)

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Tao, Tq., Mao, Hm., Xia, L. et al. Efficacy and Safety Evaluation of Taohong Siwu Decoction (桃红四物汤) for Patients with Angina Pectoris: A Meta-Analysis of Randomized Controlled Trials. Chin. J. Integr. Med. 27, 626–632 (2021). https://doi.org/10.1007/s11655-019-3028-4

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  • DOI: https://doi.org/10.1007/s11655-019-3028-4

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