Abstract
Microcirculation of liver cancer is the micro-vascular system which comes from the tissue of liver cancer. It can offer the nutritional requirement for accelerating the cancer cell proliferation and metastasis. The intrinsic mechanism of angiogenesis is the key link in the formation of liver cancer microcirculation system. Liver regeneration microenvironment also plays an important role in the construction of liver cancer microcirculation, through the improvement of liver regeneration microenvironment affecting tumor microcirculation is the new strategy of prevention and treatment of liver cancer. In recent years, it is found that many kinds of Chinese medicine can inhibit angiogenesis, decrease the microvessel density, and delay or prevent the development of liver cancer.
Similar content being viewed by others
References
Xu CY, Ni QG, Zhang LY. Tumor microenvironment and tumor angiogenesis. China Healthcare Frontiers 2009;4:2123,90.
Folkmanm J. Fundamental concepts of the angiogenic process. Curr Mol Med 2003;3:643–651.
Zhang YL, Zhou SJ, Li SW. The function of VEGF and Notch pathway in the formation of liver cancer angiogenesis. Progress Physiol Sci (Chin) 2014;45:205–208.
Li HM, Zhao BB, Gao X, Shen X, Wu Y, Zhang JR, et al. Tonifying Kidney network to modulate liver regeneration microenvironment to prevent and cure liver cancer. J Hubei Univ Tradit Chin Med (Chin) 2015;17:5–8.
Li H, Ye Q, Yin XJ, Li YM. Research progress of angiogenesis in hepatocellular carcinoma. Chin Clinic Oncol 2009;14:369–372.
Hei ZY, Wang L, Jin HM. Research progress of relationship between VEGF and angiogenesis in primary liver cancer. J Chin Microcircul (Chin) 2005;9:292–294.
Scaveni C, Vacca A, Di Pietro G, Dammacco F, Ribatti D. Crosstalk between angiogenesis and lymphangiogenesis in tumor progression. Leukemia 2004;18:1054–1058.
Coussens LM, Fingleton B, Matrisian LM. Matrix metalloproteinase inhibitors and cancer: trials and tribulations. Science 2002;295:2387–2392.
Otrock ZK, Mahfouz RA, Makarem JA, Shamseddine AI. Understanding the biology of angiogenesis: review of the most important molecular mechanisms. Blood Cells Mol Dis 2007;39:212–220.
Ding T, Xu J, Zhang Y, Guo RP, Wu WC, Zhang SD, et al. Endothelium-coated tumor clusters are associated with poor prognosis and micrometastasis of hepatocellular carcinoma after resection. Cancer 2011;117:4878–4889.
Zhong C, Wei W, Su XK, Li HD, Xu FB, Guo RP. Serum and tissue vascular endothelial growth factor predicts prognosis in hepatocellular carcinoma patients after partial liver resection. Hepatogastroenterology 2012;59:93–97.
Shi JH, Liu SZ, Wierød L, Scholz H, Anmarkrud JA, Huitfeldt HS, et al. RAF-targeted therapy for hepatocellular carcinoma in the regenerating liver. J Surg Oncol 2013;107:393–401.
Cao GW, Wang B. Interventional nursing. Beijing: People's Medical Publishing House; 2005:7173–7174.
Li HM. Construction and application of tertiary prevention program for liver cancer based on "tonifying the Kidney to promote liver regeneration and repair by affecting stem cells and their microenvironment". Chin J Integr Tradit West Med Liver Dis (Chin) 2015;25:369–372.
Li HM. Regulation of liver regeneration:Research progress and prospect. World Chin J Digestol 2015;23:3337–3343.
Sheng QS, Wang W. Research progress for the effect of preventing liver cancer angiogenesis by using traditional Chinese medicine. Chin J Integr Tradit West Med Liver Dis 2014;24:61–64.
Li PC, Wei AL, Zhang YQ, Tang QY. Research status on traditional Chinese medicine of angiogenesis in hepatocellular carcinoma. Popul Sci Technol (Chin) 2014;16:136–138.
Zhang B, Huang GX, Zhang YQ, Chen XX, Hu PL, Xu BP. Clinical observation on prevention of "Jia Wei Si Jun Zi Tang" from damage of hepatic reserving function after intervention of liver cancer. J Chin Med Mater 2004;27:387–389.
Cui YF, Zu MH, Xu H, Gu YM, Li GJ, Zhang QQ, et al. Severe complications after transcatheter arterial chemoembolization for hepatocellular carcinoma. Chin J Interv Imag Therapy 2005;2:31–33.
Huang G, Wang YQ, Tan MD, Xie HH, Li W, Liu GW. The research progress of curcumin antitumor mechanism. Anti- Tumor Pharm (Chin) 2014;4:328–331.
Li HM, Yan XS, Ming AP, Peng YQ. The effect of liposomecurcumin on inhibitory Bel-7402 cell proliferation and induction apoptosis. Chin J Integr Tradit West Med Liver Dis (Chin) 2005;15:214–217.
Li HM, Yan XS, Ming AP, Peng YQ, Gui WJ. Stability of anti-liver cancer efficacy by liposome-curcumin in water solution. Chin Tradit Herb Drugs (Chin) 2006;37:561–565.
Ni Q, Zeng SE, Tan N, Guo F, Zhang MY. Effect of curcumin on the proliferation and apoptosis of hepatocellular carcinoma Hepl cells. Shandong Med J (Chin) 2010;50:6–8.
Zhao BB, Li HM, Gao X, Ye ZH, Cheng SS. The herbal compound "Diwu Yanggan" modulates liver regeneration by affecting the hepatic stem cell microenvironment in 2-acetylaminofluorene/partial hepatectomy rats. Evid Based Complement Alternat Med 2015:468303.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Li, Hm. Microcirculation of liver cancer, microenvironment of liver regeneration, and the strategy of Chinese medicine. Chin. J. Integr. Med. 22, 163–167 (2016). https://doi.org/10.1007/s11655-016-2460-y
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11655-016-2460-y