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The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells

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Abstract

Objective

Cheongseoikki-tang (CIT, Korean), also called Qingshu Yiqi decoction (清暑益气汤) and Seisho-ekki-to (Japanese), is well known as an effective traditional combination of herbs for treating cardiovascular diseases. This study was to research its effects on bone marrow-derived mast cell (BMMC)-mediated allergy and inflammation mechanisms.

Methods

In this study, the biological effect of Cheongseoikki-tang ethanol extract (CITE) was evaluated, focusing on its effects on the production of allergic mediators by phorbol 12-myristate 13-acetate (PMA) plus calcium ionophore A23187 (A23187)-stimulated BMMCs. These allergic mediators included interleukin-6 (IL-6), prostaglandin D2 (PGD2), leukotriene C4 (LTC4), and β-hexosaminidase (β-hex).

Results

Our data revealed that CITE inhibited the production of IL-6, PGD2, LTC4, and β-hex induced by PMA plus A23187 (P<0.05).

Conclusion

These findings indicate that CITE has the potential for use in the treatment of allergy.

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Authors and Affiliations

  1. College of Pharmacy and Wonkwang Oriental Medicines Research Institute, Wonkwang University, Jeonbuk, 570-749, Republic of Korea

    Joon-Ho Keum, Ok-Hwa Kang, Sung-Bae Kim, Su-Hyun Mun, Yun-Soo Seo, Ma-Ryong Kim & Dong-Yeul Kwon

  2. Department of Oceanography, Kunsan National University, Kunsan, 573-701, Republic of Korea

    Ok-Hwa Kang & Jung-Rae Rho

  3. National Institute of Horticultural & Herbal Science, RDA, Eumsung, 369-873, Republic of Korea

    Young-Seob Lee, Chung-Berm Park, Young-Guk Kim, Yong-Il Kim & sin-Hee Han

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  1. Joon-Ho Keum
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  2. Ok-Hwa Kang
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Corresponding author

Correspondence to Dong-Yeul Kwon.

Additional information

Supported by the National Research Foundation of Korea Grant (No. NRF-2010-013-E00034) and the Grant of the Traditional Korean Medicine R&D project, Ministry of Health & Welfare, Republic of Korea (No. B120069)

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Keum, JH., Kang, OH., Kim, SB. et al. The anti-inflammatory effect of Cheongseoikki-tang ethanol extract on allergic reactions mediated by bone marrow-derived mast cells. Chin. J. Integr. Med. 19, 380–386 (2013). https://doi.org/10.1007/s11655-013-1448-0

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  • DOI: https://doi.org/10.1007/s11655-013-1448-0

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