Abstract
Objective
To observe the effect of TCM therapy for detoxification, removing stasis, and nourishing yin on corticosteroid-induced hyperlipemia in patients with systemic lupus erythematosus (SLE), and to investigate its mechanism.
Methods
One hundred and seventy patients with SLE were randomly assigned to the integrative medicine group (IM group) and the Western medicine group (WM group), 85 in each group. Also, 30 healthy subjects selected from blood donors were enrolled in the normal control (NC) group. All patients were treated mainly with prednisone, while those in the IM group were given TCM therapy additionally, and the therapeutic course for both groups was 6 successive months. The changes of serum total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), very low density lipoprotein cholesterol (VLDL-C) and apolipoprotein A (ApoA) were determined and observed. A 2-year follow-up study was carried out in 16 patients of the WM group and 25 of the IM group.
Results
Before treatment, no significant difference had been found among the three groups in the serum levels of lipids and lipoproteins. After the 6-month treatment, as compared with the WM group, the IM group showed lower levels of TC, TG, LDL-C, and VLDL-C (P<0.05 or P<0.01) and higher levels of HDL-C and ApoA (P<0.05). A similar effect was also shown by the follow-up study in the IM group (P<0.05 or P<0.01).
Conclusion
TCM therapy for detoxification, removing stasis, and nourishing yin can effectively regulate the levels of serum lipids and lipoproteins in preventing and treating SLE patients with corticosteroidinduced hyperlipemia.
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References
Fan YS, Wen CP, Li XM, et al. Clinical observation of hormone combined with Jiedu Quyu Ziyin Therapy in treatment of systemic lupus erythematosus. Chin J Integr Tradit West Med 1999;19(10): 626–627.
Fan YS, Wen CP, Wu GL, et al. Investigation into preventive and therapeutic effects of Jieduquyuziyin methods in treating corticosteroid osteoporosis in systemic lupus erythematosus. China J Tradit Chin Med Pharm 2005;20(11):667–669.
Wen CP, Fan YS, Tang XY, et al. Investigation on the effect of JieDuQuYuZiYin methods on regulating the abnormal function of thyroid in systemic lupus erythematosus. Chin Arch Tradit Chin Med 2006; 24(7):1229–1232.
Chen ZQ, translated. New standards of systemic lupus erythematosus reviesed by American Rheumatism Association. For Med Sci: Dermatol 1998;24(6):367.
Bombardies C, Gladman DD, Urowitz, et al. Derivation of the SLEDAI: a disease activity index for lupus patients. Arthritis Rheum 1992; 35:630–640.
Petri M, Spence D, Bone LR. Coronary artery disease risk factors in the John Hopkins Lupus Cohort: prevalence recognition by patients, and preventive practices. Medicine (Baltimore) 1992;1:291–302.
Li YQ, Jiang MY, editors. Pharmacology of traditional Chinese drug. Beijing: China Press of Traditinal Chinese Medicine, 1992: 129.
Liang RN, Chen MR, Xu X, et al. Effect of Dandi Tablet on blood lipids and sex hormones in women of postmenopausal stage. Chin J Integr Tradit West Med 2003;23(8):593–595.
Duan P, Chen DZ, Niu JZ, et al. Effect of Compound Bjiejia Ruangan Tablet on lipids in rats with adiposis hepatica. China J Tradit Chin Med Pharm 2005;20(6):375–376.
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Supported by the Foundation of State Administration of Traditional Chinese Medicine (No. 02-03LP30)
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Wen, Cp., Fan, Ys., Wang, Xc. et al. Effect of detoxification, removing stasis and nourishing yin method on corticosteroid-induced hyperlipidemia in patients with systemic lupus rythematosus. Chin. J. Integr. Med. 13, 180–184 (2007). https://doi.org/10.1007/s11655-007-0180-z
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DOI: https://doi.org/10.1007/s11655-007-0180-z