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Depression and Anxiety Changes Among Sexual and Gender Minority People Coinciding with Onset of COVID-19 Pandemic


With SARS-COV-2 recently sweeping the globe, the population is experiencing a group stressor unlike any phenomenon in this country in the last century. How the pandemic experience is related to mental health challenges including anxiety and depression is unknown. Numerous factors—such as changes in community function; restriction of activities and social contacts; and fearfulness about the virus, the economic downturn, and food access—may contribute to poorer mental health. Marginalized populations, such as sexual and gender minority people (i.e., non-heterosexual people and transgender or gender-expansive people, respectively) may be particularly at risk for adverse impacts of the pandemic due to preexisting economic and health factors.1 We set out to document changes in depression and anxiety within The PRIDE Study, a longitudinal cohort of sexual and gender minority people, a vulnerable population.2


Participants in The PRIDE Study, a longitudinal cohort study of sexual and gender minority people,2 were included if they completed mental health measures in the 2019 Annual Questionnaire (timepoint 1, June 2019—ongoing at time of data extraction) and in a COVID-19 impact ancillary study (timepoint 2, March 23, 2020, through April 19, 2020). Paired sample t tests examined changes in depression (9-item Patient Health Questionnaire, PHQ-93) and anxiety (7-item Generalized Anxiety Disorder Scale, GAD-74) symptoms overall and separately among those who screened positive (PHQ-9 and GAD-7 scores ≥ 103, 4) and negative (scores < 10) for depression and generalized anxiety disorder at timepoint 1.


In total, 2288 participants were included in this study (see Table 1 for participant characteristics). Depression symptoms increased by a mean PHQ-9 score of 1.21 (t[2280] = 11.35, p < .001, d = .20) from timepoint 1 to 2. Anxiety symptoms increased by a mean GAD-7 score of 3.11 (t[2282] = 27.95, p < .001, d = .54). Among individuals who screened positive for depression at timepoint 1, PHQ-9 scores decreased by a mean of 1.08 (t[670] = − 4.80, p < .001, d = .21) at timepoint 2. Among individuals who screened negative for depression at time 1, PHQ-9 scores increased by a mean of 2.17 (t[1609] = 19.58, p < .001, d = 0.53) at timepoint 2. Among individuals who screened positive for generalized anxiety at timepoint 1, there was no change in GAD-7 scores (t[508] = 1.01, p = .32, d = .06). Among individuals who screened negative for generalized anxiety at timepoint 1, GAD-7 scores increased by a mean of 3.93 (t[1773] = 32.93, p < .001, d = .88) at timepoint 2.

Table 1 Demographic characteristics of N = 2288 sexual and gender minority individuals


We found increases in anxiety and depression coinciding with the COVID-19 pandemic onset. Increased anxiety and depression symptoms were driven by people who did not have preexisting symptoms consistent with generalized anxiety or depression. While this study was conducted with sexual and gender minority people, the results may be relevant for other vulnerable populations, such as other minority groups.

Health care providers are advised to check in with patients about stress and to screen for mood and anxiety disorders, even among patients who had no prior history of anxiety or depression. Treatment and referrals can include traditional interventions such as individual therapy and medications and may also include COVID-19-specific supports implemented on a larger scale (e.g., supportive peer-led groups, mindfulness practice). This study is observational. Our finding that individuals with preexisting depression had improved mood from timepoint 1 to 2 may represent regression to the mean and should not be interpreted that these individuals have less depressive symptoms, as they already were experiencing symptoms of depression at timepoint 1. Future research will identify who is most at risk for adverse impact. In the interim, we should consider ways to support the mental health of all of our communities during the pandemic, with special care and attention to vulnerable populations.


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The PRIDE Study is a community-engaged research project that serves and is made possible by LGBTQ+ community involvement at multiple points in the research process, including the dissemination of findings. We acknowledge the courage and dedication of The PRIDE Study participants for sharing their stories; the careful attention of PRIDEnet Participant Advisory Committee (PAC) members for reviewing and improving every study application; and the enthusiastic engagement of PRIDEnet Ambassadors and Community Partners for bringing thoughtful perspectives as well as promoting enrollment and disseminating findings. For more information, please visit


A.F. was partially supported by the National Institute on Drug Abuse (grant number K23DA039800). J.O.M. was partially supported by the National Institute of Diabetes, Digestive, and Kidney Disorders (grant number K12DK111028). Research reported in this article was partially funded through a Patient-Centered Outcomes Research Institute (PCORI) Award (award number PPRN-1501-26848) to M.R.L. The statements in this article are solely the responsibility of the authors and do not necessarily represent the views of PCORI, its Board of Governors or Methodology Committee, nor of the National Institutes of Health. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.

A.F. had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.

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Correspondence to Annesa Flentje PhD.

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Flentje, A., Obedin-Maliver, J., Lubensky, M.E. et al. Depression and Anxiety Changes Among Sexual and Gender Minority People Coinciding with Onset of COVID-19 Pandemic. J GEN INTERN MED 35, 2788–2790 (2020).

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