Abstract
Background
The aim of this study is to assess the impact of frailty on short-term outcomes after hepatectomy for colorectal liver metastasis (CRLM).
Methods
Patients were identified using the National Surgical Quality Improvement Program (NSQIP). Patients were divided into 3 categories using the 5-item Modified Frailty Index (mFI).
Results
There were 5230 patients included. 52%, 35%, and 13% had mFI scores of 0, 1, and ≥ 2 respectively. Patients with a ≥ 2 mFI score were more likely to experience minor complication (OR 1.34, 95% CI 1.06–1.69), major complication (OR 1.56, 95% CI 1.15–2.12), readmission (OR 1.55, 95% CI 1.12–2.14), unfavorable discharge (OR 2.48, 95% CI 1.62–3.80), 30-day mortality (OR 3.02, 95% CI 1.02–8.95), prolonged length of stay (OR 1.47, 95% CI 1.18–1.83), and bile leak (OR 1.51, 95% CI 1.02–2.24).
Conclusion
Frailty is associated with increased post-operative complications. The 5-item mFI can guide risk stratification, optimization, and counseling.
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Study Design and Conception: JD, MH, AA, BJ, TR, MK
Data Acquisition: JD, CO, CH
Statistical Analysis: JD, CO, CH
Manuscript Writing: JD, MH, AA, CO, CH, BJ, TR, MK
Critical Revision: JD, MH, AA, CO, CH, BJ, TR, MK
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The American College of Surgeons National Surgical Quality Improvement Program and the hospitals participating in the ACS NSQIP are the source of the data used herein; they have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.
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Dauch, J., Hamidi, M., Arrington, A.K. et al. The Impact of Frailty on Patients Undergoing Liver Resection for Colorectal Liver Metastasis. J Gastrointest Surg 26, 608–614 (2022). https://doi.org/10.1007/s11605-021-05149-0
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DOI: https://doi.org/10.1007/s11605-021-05149-0