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Transhepatic Direct Approach to the “Limit of the Division of the Hepatic Ducts” Leads to a High R0 Resection Rate in Perihilar Cholangiocarcinoma

  • Original Article
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Journal of Gastrointestinal Surgery

Abstract

Background

Previous studies have shown that curative resection (R0 resection) was among the most crucial factors for the long-term survival of patients with PHCC. To achieve R0 resection, we performed the transhepatic direct approach and resection on the limits of division of the hepatic ducts. Although a recent report showed that the resection margin (RM) status impacted PHCC patients’ survival, it is still unclear whether RM is an important clinical factor.

Objective

To describe a technique of transhepatic direct approach and resection on the limit of division of hepatic ducts, investigate its short-term surgical outcome, and validate whether the radial margin (RM) would have a clinical impact on long-term survival of perihilar cholangiocarcinoma (PHCC) patients.

Methods

Consecutive PHCC patients (n = 211) who had undergone major hepatectomy with extrahepatic bile duct resection, without pancreaticoduodenectomy, in our department were retrospectively evaluated.

Results

R0 resection rate was 92% and 86% for invasive cancer-free and both invasive cancer-free and high-grade dysplasia-free resection, respectively. Overall 5-year survival rate was 46.9%. Univariate analysis showed that preoperative serum carcinoembryonic antigen level (> 7.0 mg/dl), pathological lymph node metastasis, and portal vein invasion were independent risk factors, but R status on both resection margin and bile duct margin was not an independent risk factor for survival.

Conclusion

The transhepatic direct approach to the limits of division of the bile ducts leads to the highest R0 resection rate in the horizontal margin of PHCC. Further examination will be needed to determine the adjuvant therapy for PHCC to improve patient survival.

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Authors and Affiliations

  1. Faculty of Medicine, Department of Gastroenterological Surgery II, Hokkaido University, Kita 15 Nishi 7, Kita-ku, Sapporo, Hokkaido, 060-8638, Japan

    Takehiro Noji, Kimitaka Tanaka, Aya Matsui M.D, Ph.D., Yoshitsugu Nakanishi, Toshimichi Asano, Toru Nakamura, Takahiro Tsuchikawa, Keisuke Okamura & Satoshi Hirano

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  1. Takehiro Noji
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  2. Kimitaka Tanaka
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  3. Aya Matsui M.D, Ph.D.
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  4. Yoshitsugu Nakanishi
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  5. Toshimichi Asano
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Correspondence to Takehiro Noji.

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Noji, T., Tanaka, K., Matsui, A. et al. Transhepatic Direct Approach to the “Limit of the Division of the Hepatic Ducts” Leads to a High R0 Resection Rate in Perihilar Cholangiocarcinoma. J Gastrointest Surg 25, 2358–2367 (2021). https://doi.org/10.1007/s11605-020-04891-1

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  • DOI: https://doi.org/10.1007/s11605-020-04891-1

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