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Guidelines for the Treatment of Hepatocellular Adenoma in the Era of Molecular Biology: An Experience-Based Surgeons’ Perspective

  • Original Article
  • Published:
Journal of Gastrointestinal Surgery

Abstract

Background

Hepatocellular adenoma (HA) is a rare benign liver tumor with increasing incidence affecting young women. In the last years, much has changed in diagnosis, classification, and treatment, due to the identification of different molecular subtypes. With the evolving knowledge, especially on molecular characteristics of the disease, we are far from a consensus of how to deal with such a multifaceted benign disease

Methods

In the last 20 years, we have treated 134 patients with HA with a mean age of 28 years, being 126 women. Fifty patients had a history of abdominal pain and 13 patients had an acute episode of pain due to rupture and bleeding. Until 2009, adenomas larger than 4 cm in diameter were resected, regardless of gender. From 2010 to 2016, only adenomas larger than 5 cm were referred for surgical treatment. Since 2016, resection was indicated in all female patients with non-steatotic adenomas larger than 5 cm and all adenomas in men.

Results and Discussion

One hundred twenty-four patients were submitted to resection, being in 21 major resections. Since 2010, 74% of resections were done laparoscopically. Patients with ruptured adenomas were treated with transarterial embolization. Morbidity rate was 8.1% with no mortality. Authors discuss point-by-point all the aspects and presentations of the disease and the best approach. We proposed a therapeutic guideline based on the best available evidence and in our experience.

Conclusions

Due to the complexity of the disease, the treatment of HA is one the best examples of an individualized approach.

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Authors and Affiliations

  1. Digestive Surgery Division, Department of Gastroenterology, University of São Paulo School of Medicine, São Paulo, Brazil

    Paulo Herman, Gilton Marques Fonseca, Jaime Arthur Pirola Kruger, Vagner Birk Jeismann & Fabricio Ferreira Coelho

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  1. Paulo Herman
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Herman, P., Fonseca, G.M., Kruger, J.A.P. et al. Guidelines for the Treatment of Hepatocellular Adenoma in the Era of Molecular Biology: An Experience-Based Surgeons’ Perspective. J Gastrointest Surg 25, 1494–1502 (2021). https://doi.org/10.1007/s11605-020-04724-1

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