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How to Perform Safe and Technically Optimized Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Experience After a Consecutive Series of 1200 Procedures

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Journal of Gastrointestinal Surgery

Abstract

Pressurized intraperitoneal aerosol chemotherapy (PIPAC) is a new approach to deliver intraperitoneal chemotherapy as a pressurized aerosol in patients with advanced peritoneal metastases (PM). Although this treatment has rapidly been adopted into clinical practice, most surgeons are not familiar with the basics and principles of this technology. The purpose of this article is to review patient selection criteria, as well as highlighting important operative and technical details regarding PIPAC technology with a focus on “how to do it.” To this end, safety and feasibility data from a series of 1200 consecutive PIPAC procedures performed by two pioneers of PIPAC treatment are presented.

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Authors and Affiliations

  1. Department of General Surgery and Therapy Center for Peritoneal Carcinomatosis, Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Germany

    Urs Giger-Pabst

  2. Basic Research Laboratories, Department of Surgery, Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Germany

    Urs Giger-Pabst

  3. Department of General Surgery, Visceral and Transplant Surgery, University Hospital Münster, Albert-Schweitzer-Campus 1, 48149, Münster, Germany

    Urs Giger-Pabst

  4. Department of Obstetrics and Gynecology, Marien Hospital Herne, Ruhr-Universität Bochum, Herne, Germany

    Clemens B. Tempfer

Authors
  1. Urs Giger-Pabst
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  2. Clemens B. Tempfer
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Contributions

UGP: PIPAC procedures, data collection, data analysis, drafting, and critical revision for important intellectual content of the manuscript.

CBT: PIPAC procedures and critical revision for important intellectual content of the manuscript.

Corresponding author

Correspondence to Urs Giger-Pabst.

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Giger-Pabst, U., Tempfer, C.B. How to Perform Safe and Technically Optimized Pressurized Intraperitoneal Aerosol Chemotherapy (PIPAC): Experience After a Consecutive Series of 1200 Procedures. J Gastrointest Surg 22, 2187–2193 (2018). https://doi.org/10.1007/s11605-018-3916-5

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  • DOI: https://doi.org/10.1007/s11605-018-3916-5

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