Journal of Gastrointestinal Surgery

, Volume 22, Issue 8, pp 1376–1384 | Cite as

The Relationship Between Age and Chronic Kidney Disease in Patients Undergoing Pancreatic Resection

  • Derrick Antoniak
  • Chandrakanth Are
  • Chad Vokoun
  • Kaeli Samson
  • Lynette Smith
  • Jason Shiffermiller
Original Article



Severe chronic kidney disease (CKD) predicts adverse outcomes in patients undergoing pancreatectomy, but the impact of milder CKD is unknown. Additionally, some authors have suggested that, due to physiologic changes of aging, CKD is over-diagnosed in patients above age 65.


Patients undergoing pancreatectomy for malignancy from 2005 to 2014 were identified from the National Surgical Quality Improvement Program. Primary outcomes were all-cause mortality and major complication, defined as myocardial infarction, cardiac arrest, stroke, venous thromboembolism, respiratory failure, deep surgical site infection, pneumonia, acute kidney injury, coma > 24 h, or re-operation occurring within 30 days of surgery.


The mean age of 16,173 participants was 66 (range 18–90). Median preoperative creatinine was 0.80 mg/dL (0.10–11.0), and median preoperative eGFR was 86.36 mL/min/1.73m2 (2.98–182.2). Mortality and major complication occurred in 3 and 23% of patients, respectively. In adjusted analyses, CKD stages 2 (adjusted odds ratio (aOR) 1.24, 95% confidence interval (CI) 1.10–1.40), 3a (aOR 1.50, 95% CI 1.24–1.82), 3b (aOR 1.56, 95% CI 1.19–2.06), and 4 (aOR 2.17, 95% CI 1.25–3.76) were associated with increased major complication, and CKD stage 4 was associated with increased mortality (aOR 2.68, 95% CI 1.10–6.56). Age did not influence the relationship between CKD and either outcome.


CKD of any stage was associated with an increased risk of postoperative major complication, and severe CKD was associated with increased mortality among patients undergoing pancreatectomy for malignancy. These associations were not diminished in elderly patients. Our findings could inform preoperative counseling and decision-making.


Pancreatic cancer Chronic renal insufficiency Glomerular filtration rate Perioperative period NSQIP 



The American College of Surgeons National Surgical Quality Improvement Program and the hospitals participating in the ACS NSQIP are the source of the data used herein; they have not verified and are not responsible for the statistical validity of the data analysis or the conclusions derived by the authors.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflicts of interest.


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Copyright information

© The Society for Surgery of the Alimentary Tract 2018

Authors and Affiliations

  • Derrick Antoniak
    • 1
    • 2
  • Chandrakanth Are
    • 3
  • Chad Vokoun
    • 1
  • Kaeli Samson
    • 4
  • Lynette Smith
    • 4
  • Jason Shiffermiller
    • 1
  1. 1.Department of Medicine, Division of General Internal Medicine – AcademicUniversity of Nebraska Medical CenterOmahaUSA
  2. 2.Department of MedicineVeterans Affairs Nebraska Western Iowa Health Care SystemOmahaUSA
  3. 3.Department of Surgery, Division of Surgical Oncology, Fred and Pamela Buffett Cancer CenterUniversity of Nebraska Medical CenterOmahaUSA
  4. 4.Department of Biostatistics, College of Public HealthUniversity of Nebraska Medical CenterOmahaUSA

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