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Simultaneous Liver and Colorectal Resections Are Safe for Synchronous Colorectal Liver Metastases

  • Original Article
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Journal of Gastrointestinal Surgery Aims and scope

Abstract

Background

Hepatic resection (HR) is the only option offering a potential cure for patients with synchronous colorectal cancer liver metastases (SCRLM). The optimal timing of HR for SCRLM is still controversial. This study aimed to determine whether simultaneous HR is similar to staged resection regarding the morbidity and mortality rates in patients with SCRLM.

Methods

Four hundred and five consecutive patients with SCRLM were treated with either simultaneous (n = 129) or staged (n = 276) HR. The postoperative complications were analyzed retrospectively according to the documented records and hepatectomy databases at the Gastrointestinal Institute.

Results

Perioperative morbidity and mortality did not differ between simultaneous resections and staged resections for selected patients with SCRLM (morbidity, 47.3% versus 54.3%; mortality, 1.5% versus 2.0%, respectively; both p > 0.05). Simultaneous liver resections of three or more segments would not increase the rate of complications compared to staged resections (56.8% and 42.4%, respectively; p = 0.119). Meanwhile, patients with simultaneous resections experienced shorter duration of surgery and postoperative hospitalization time as well as less blood loss during surgery (all p < 0.05).

Conclusions

Simultaneous resections of colorectal cancer primary lesions and hepatic metastases were safe and could serve as a primary option for selected SCRLM patients.

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Acknowledgements

We thank Dr. Andrew Kaz and Pin-Zhu Huang for his critical comments regarding this study. This work was supported by the Guangdong Provincial Scientific Research Grants (06104601, JP Wang), the National Natural Scientific Foundation of China Grants (30872488 AQ3, L Wang), and Yat-sen Innovative Talents Cultivation Program for Excellent Tutors (88000-3126200, YX Luo and JP Wang).

Conflicts of interest

We declare there are no financial or commercial conflicts of interest in this study.

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Authors and Affiliations

  1. Department of Colorectal Surgery, Gastrointestinal Institute, The Sixth Affiliated Hospital, Sun Yat-Sen University, 26 Yuancunerheng Rd, Guangzhou, 510655, People’s Republic of China

    Yanxin Luo, Lei Wang, Dianke Chen, Meijin Huang, Junsheng Peng, Ping Lan & Jianping Wang

  2. Department of Gastrointestinal Surgery, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, People’s Republic of China

    Chuangqi Chen, Yihua Huang, Ji Cui & Shirong Cai

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  1. Yanxin Luo
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  2. Lei Wang
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  4. Dianke Chen
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  5. Meijin Huang
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  6. Yihua Huang
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  9. Ji Cui
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  10. Shirong Cai
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  11. Jianping Wang
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Correspondence to Jianping Wang.

Additional information

Yanxin Luo, Lei Wang, and Chuangqi Chen contributed equally to this work.

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Luo, Y., Wang, L., Chen, C. et al. Simultaneous Liver and Colorectal Resections Are Safe for Synchronous Colorectal Liver Metastases. J Gastrointest Surg 14, 1974–1980 (2010). https://doi.org/10.1007/s11605-010-1284-x

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  • DOI: https://doi.org/10.1007/s11605-010-1284-x

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