Abstract
Objectives
To investigate the usefulness of machine learning (ML) models using pretreatment 18F-FDG-PET-based radiomic features for predicting adverse clinical events (ACEs) in patients with cardiac sarcoidosis (CS).
Materials and methods
This retrospective study included 47 patients with CS who underwent 18F-FDG-PET/CT scan before treatment. The lesions were assigned to the training (n = 38) and testing (n = 9) cohorts. In total, 49 18F-FDG-PET-based radiomic features and the visibility of right ventricle 18F-FDG uptake were used to predict ACEs using seven different ML algorithms (namely, decision tree, random forest [RF], neural network, k-nearest neighbors, Naïve Bayes, logistic regression, and support vector machine [SVM]) with tenfold cross-validation and the synthetic minority over-sampling technique. The ML models were constructed using the top four features ranked by the decrease in Gini impurity. The AUCs and accuracies were used to compare predictive performances.
Results
Patients who developed ACEs presented with a significantly higher surface area and gray level run length matrix run length non-uniformity (GLRLM_RLNU), and lower neighborhood gray-tone difference matrix_coarseness and sphericity than those without ACEs (each, p < 0.05). In the training cohort, all seven ML algorithms had a good classification performance with AUC values of > 0.80 (range: 0.841–0.944). In the testing cohort, the RF algorithm had the highest AUC and accuracy (88.9% [8/9]) with a similar classification performance between training and testing cohorts (AUC: 0.945 vs 0.889). GLRLM_RLNU was the most important feature of the modeling process of this RF algorithm.
Conclusion
ML analyses using 18F-FDG-PET-based radiomic features may be useful for predicting ACEs in patients with CS.
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Introduction
Sarcoidosis is a systemic granulomatous inflammatory disease of unknown etiology. Cardiac involvement is clinically rare, and it only occurs in 5% of patients with sarcoidosis [1, 2]. However, cardiac sarcoidosis (CS) is an important predictor of poor prognosis in patients with sarcoidosis due to complications such as atrioventricular block (AVB), ventricular tachycardia (VT), and congestive heart failure [3,4,5]. Thus, it is extremely important to make early diagnosis and evaluate disease activity for managing patients with CS [6, 7].
Glucose metabolic activity can be evaluated by measuring 18F-FDG uptake during PET/computed tomography (CT) scan for not only oncological but also inflammatory disorders [8, 9]. However, only a few studies have used 18F-FDG-PET-based radiomic features for diagnosing or predicting treatment response in CS [10, 11]. Recently, the potential applications of machine learning (ML) analysis have been reported in the field of nuclear cardiology [12,13,14]. However, to the best of our knowledge, no study has examined the efficacy of the ML approach using 18F-FDG-PET-/CT-based radiomics on predicting adverse clinical events (ACEs) in patients with CS.
The current study aimed to investigate the usefulness of ML models using pretreatment 18F-FDG-PET-based radiomic features for predicting the risk of ACEs in patients with CS.
Materials and methods
Patients
This retrospective study was approved by the institutional review board, and the need for informed consent was waived. In total, 70 consecutive patients with known or suspected CS underwent pretreatment 18F-FDG-PET/CT scan from April 2012 to December 2022. Their clinical records were reviewed to identify patients who should be evaluated.
In a previous study [15], the usefulness of Patlak Ki images extracted from dynamic 18F-FDG-PET/CT scan for evaluating the risk of clinical events in CS was examined. The previous study enrolled 21 patients with CS who underwent 30 18F-FDG-PET/CT scan, which included pretreatment, undertreatment, and follow-up scans, between April 2019 and January 2020. However, analyses using ML approaches for predicting the risk of ACEs in patients with CS using pretreatment 18F-FDG-PET-based radiomic features were not performed. Thus, among 21 patients, 8 with pretreatment 18F-FDG-PET/CT scans were included in the current study. The inclusion criteria were as follows: (1) patients diagnosed with CS according to the Japanese Society of Sarcoidosis and Other Granulomatous Disorders guidelines [16], (2) those without a history of steroid treatment, and (3) those with visible cardiac 18F-FDG uptake on PET/CT scan. The exclusion criteria were patients with a history or coexistence of other cardiac disorders.
Of 70 patients, 12 without cardiac 18F-FDG uptake were excluded. Among the remaining 58 patients, 11 were further excluded because of hypertrophic cardiomyopathy (n = 2), dilated cardiomyopathy (n = 2), ventricular aneurysm (n = 1), and lack of CS evidence (n = 6).
Finally, 47 patients (38 women and 9 men; mean age: 61 ± 10 [age: 39–81] years) were eligible for the analyses. Immunosuppressive treatment was adopted for these patients after the pretreatment 18F-FDG-PET/CT scan according to the recommendations of the Japanese Society of Sarcoidosis and Other Granulomatous Disorders guidelines [16]. The loading dose of prednisolone was 30 mg/day, which was tapered to a maintenance dose and administrated to all patients during the follow-up period.
Imaging protocols
All patients were instructed to follow a high-fat and low-carbohydrate diet for 1 day, and followed by a fast of at least 18 h before 18F-FDG-PET/CT scan, which resulted in a mean plasma glucose level of 102 (range: 71–154) mg/dL immediately before intravenous 18F-FDG administration.
All 18F-FDG-PET/CT scan procedures were performed using two whole-body PET/CT scanners. The Discovery 600M PET/CT scanner (GE Healthcare, Milwaukee, WI, the USA) was used from April 2012 to January 2018 and the Discovery MI scanner (GE Healthcare) from February 2018 to December 2022. The emission scan was performed 1 h after the administration of 18F-FDG (mean: 223 ± 30 [155–277] MBq) after CT data acquisition (slice thickness: 3.75 mm, pitch: 1.375 mm, 120 keV, auto mA: 40–100 mA, based on body mass, and reconstructed matrix size: 512 × 512). The acquisition time was 2.5 min per bed position (total: 7–11). Attenuation-corrected data were acquired. Using the Discovery 600M scanner, images were reconstructed with a three-dimensional ordered subset expectation–maximization algorithm (image matrix size: 192 × 192, 16 subsets, two iterations, voxel size: 3.125 × 3.125 × 3.27 mm3, and VUE Point Plus). Using the Discovery MI scanner, a Bayesian penalized likelihood reconstruction algorithm was used (image matrix size: 192 × 192, voxel size: 2.60 × 2.60 × 2.78 mm3, penalization factor: 700, and Q. Clear) with the point spread function. Each scanner used a consistent reconstruction setting and matrix.
Image and radiomic feature analyses
Two radiologists (with 12 and 20 years of 18F-FDG-PET/CT scan experience) who were knowledgeable about the study purpose but were blinded to the clinical information read the 18F-FDG PET/CT scan images. The radiologists visually assessed each 18F-FDG-PET/CT scan image as negative (myocardial visibility lower than or similar to that of the liver) or positive (myocardial visibility higher than that of the liver) 18F-FDG uptake [17] in the left ventricle (LV) and right ventricle (RV) myocardium. In case of a disagreement, they reached a consensus.
A third radiologist (18 years of 18F-FDG-PET/CT experience) performed quantitative analyses of the visible myocardial lesions. The third radiologist generated the volume of interest (VOI) by manually placing a region of interest on a suitable reference-fused axial image, and defined the craniocaudal and mediolateral extents encompassing the whole positive myocardial lesion, excluding any avid extracardiac structures. Next, the maximum standardized uptake value (SUVmax) threshold was set at 40%, which was commonly used in previous studies [18], to automatically delineate a VOI equal to or greater than the 40% threshold of SUVmax. The LIFEx package (version 6.00) [19] was used to extract 49 radiomic features from PET images (Supplemental Table 1). The LIFEx package is used to calculate textural features only for VOIs of at least 64 voxels. These 49 radiomic features were included in five categories (shape and first-order characteristics, gray level co-occurrence matrix, neighborhood gray-tone difference matrix [NGTDM], gray level run length matrix [GLRLM], and gray level zone length matrix). The VOI and SUV were resampled into discrete bins using absolute resampling to minimize the correlation between textural features and reduce the impact of noise and matrix size [20]. Sixty-four bins were used for the PET component with the minimum and maximum bounds of the resampling interval set to SUVs of 0 and 20, respectively. Moreover, the voxel size was resampled to 3.0 × 3.0 × 3.0 mm3. Therefore, a bin size with an SUV of 0.3 was used to analyze the PET component. Voxels with an SUV of > 20 were grouped in the highest bin [20].
As we used two different PET scanners, post-reconstruction harmonization was performed for all PET parameters using the ComBat harmonization method for R software (https://github.com/Jfortin1/ComBatHarmonization) [21], which is effective in PET scans [22].
Confirmation of ACEs
Echocardiography was performed within 2 months of 18F-FDG-PET/CT scan (mean ± standard deviation: 13 days ± 14 [range: − 50 to + 58 days]). The echocardiography report was used as the reference standard for cardiac function. Cardiac dysfunction was defined as a LV ejection fraction (LVEF) of < 50% [23]. Further, twelve-lead or Holter echocardiography was performed within 2 months of 18F-FDG-PET/CT scan (mean ± standard deviation: 17 days ± 15 [range: − 50 to + 58 days]). Moreover, patients were assessed to determine the presence of arrhythmic events, including sustained VT and AVB. AVB was characterized as either second- or third-degree AVB or trifascicular block [23, 24].
Medical records were used to obtain information on patient prognosis. The last follow-up was conducted in December 2023. ACE was defined as the reduction in LVEF with cardiac dysfunction (LVEF of < 50%), hospitalization due to cardiac arrhythmia such as recurrence or onset of sustained VT and AVB or heart failure, and death [25, 26]. Change in LVEF was determined by comparing the findings between echocardiography studies performed nearest to the pretreatment PET study and the last echocardiography studies of the follow-up period. Decrease in LVEF was defined as a negative change in LVEF.
ML approach
We adopted 49 radiomic features and the visibility of RV 18F-FDG uptake to predict ACEs using the ML approaches. Data were stratified according to event and were randomly assigned into the training (80%) and testing (20%) cohorts. Based on the ML analysis for predicting ACEs, decision tree, random forest (RF), neural network, k-nearest neighbors (kNN), Naïve Bayes, logistic regression (LR), and support vector machine (SVM), which are popular ML algorithms, were used for binary classification [27, 28].
The parameter selection for each ML method in this study was carefully made based on the specific clinical challenges and the characteristics of our dataset. For the decision tree, we limited node levels and split thresholds to prevent overfitting, and consequently we selected an induce binary tree with two minimum number of instances in leaves, a split greater than 5, with maximum 100 node levels for depth of classification tree and stop splitting the nodes after majority reach 95%. In the RF, a moderate number of trees were chosen to balance the model’s generalizability and computational efficiency, and consequently we selected 10 trees and did not split subsets smaller than 5. The neural network settings were optimized with rectified linear unit (ReLU) activation function and Adam optimization for efficient learning and good convergence, and consequently we selected 1000 neurons, alpha = 0.00001 and maximum iterations 1000. For kNN, setting the number of neighbors to 5 with metric Euclidean and weight uniform ensured suitable accuracy for our dataset size. The parameters for LR and SVM were chosen to optimize the tradeoff between model complexity and the risk of overfitting. Consequently, we selected a ridge with a coefficient score of 1 for LR. For SVM, we selected the Kernel radial basis function with cost 1 and regression loss epsilon 0.10, and the two optimization parameters, tolerance and iteration limit were set to 0.0010 and 500, respectively. In the case of Naïve Bayes, its simplicity and effective learning ability based on the distribution of data were valued. These parameter choices enabled us to construct robust and reliable predictive models aligned with the objectives of our study.
To overcome imbalanced data, the synthetic minority over-sampling technique was used in the training cohorts [29]. In this study, the sample size was small, and the set of features was reduced to prevent the influence of overfitting. The ranking-based method was only applied on the training cohort to reduce set features based on the decrease in Gini impurity. As a rule of thumb, it is necessary to use < 10% of the sample size as the number of features for classification problem [30]. The final sample size of this study was n = 47; thus, we selected the 4 top ranking features for constructing each ML model. Moreover, the use of a resampling technique referred to as k-fold cross-validation is one of the solutions of overfitting [31, 32]. Tenfolds are a common choice for k-fold cross-validation, particularly if the dataset is not extremely large or small [32]. In this study, a tenfold cross-validation was used to minimize the negative influence of overfitting on the training cohort.
Receiver operating characteristic curve (ROC) analysis was performed to compare the predictive performances of the models, and the area under the ROC curve (AUC) was calculated. The computed performance measures were AUC, accuracy, F1 score, precision (positive predictive value), and recall (sensitivity) for average over classes. The F1 score (F score or F measure) is the harmonic average between precision and recall [33]. Each ML algorithm was used to calculate each probability score (range: 0–1) of ACEs. The predictive performance of each machine model was independently estimated in the testing set by quantifying the AUC, accuracy, F1 score, precision, and recall.
The diagnostic indices including sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the testing cohort were also calculated. The importance of features in the ML modeling process was calculated using the decrease in AUC [34]. A higher decrease in AUC for a feature indicates that such a variable has a higher importance [34].
The ML analysis was performed using Orange version 3.24.1 (Bioinformatics Laboratory, University of Ljubljana, Ljubljana, Slovenia), an open-source data-mining and visualization package [35].
Statistical analysis
The Mann–Whitney U test or the Chi-square test was used to appropriately assess differences between two quantitative variables or compare categorical data. The DeLong method was used to analyze the statistical significance of differences between AUCs [36]. The diagnostic indices including sensitivity, specificity, PPV, NPV, and accuracy were compared using the McNemar’s test or Chi-square test.
Data were presented as medians and interquartile ranges (IQRs). A p value of < 0.05 was considered statistically significant, and all p values were two-tailed. The MedCalc statistical software (MedCalc Software Ltd., Acacialaan 22, 8400 Ostend, Belgium) was used for statistical analyses.
Results
Characteristics of the patients
Of 47 patients, the median LVEF was 50.0% (IQR: 38.3%–63.8% [range: 20.8–81.0%]), and cardiac dysfunction was observed in 22 patients and arrhythmic events in 16 patients before treatment. There were seven patients with positive RV 18F-FDG uptake on the pretreatment 18F-FDG-PET/CT scans. The mean follow-up duration was 48.6 (range: 7–139) months. Of 47 patients, 17 presented with ACEs during follow-up: 11 patients were hospitalized because of cardiac arrhythmia (n = 6) and heart failure (n = 5), five patients had worsening of systolic LV function and one patient died. The complication rate of ACEs was significantly higher in patients with positive RV 18F-FDG uptake than in patients with negative RV 18F-FDG uptake (85.7% [6/7] vs. 27.5% [11/40], p = 0.006).
Table 1 shows the clinical characteristics of the participants in the training and testing cohorts. Of 38 patients in the training cohort, the median LVEF was 49.0% (IQR: 36.5–63.9% [range: 20.8–81.0%]) and cardiac dysfunction was observed in 19 patients and arrhythmic events in 13 patients before treatment. There were seven patients with positive RV 18F-FDG uptake on the pretreatment 18F-FDG-PET/CT scans. Fourteen patients developed ACEs during follow-up: eight patients were hospitalized because of cardiac arrhythmia (n = 4) or heart failure (n = 4), five patients had worsening of systolic LV function, and one patient died.
Of nine patients in the testing cohort, the median LVEF was 54.4% (IQR: 43.9–64.0% [range: 30.3–74.1%]), and cardiac dysfunction was observed in three patients and arrhythmic events in three patients before treatment. Three patients developed ACEs during follow-up: all three patients were hospitalized because of cardiac arrhythmia (n = 2) or heart failure (n = 1).
No significant differences were observed in terms of LVEF, cardiac dysfunction, arrhythmic events, RV 18F-FDG uptake, and ACEs between the training and testing cohorts (each, p > 0.05).
ML models for predicting ACEs
Radiomic features were ranked based on the decrease in Gini impurity (Supplemental Table 2). The top four features for predicting ACEs were surface area, GLRLM_RLNU, coarseness from the NGTDM (NGTDM_Coarseness), and sphericity. Patients who experienced ACEs had a significantly higher surface area (p < 0.001), GLRLM_RLNU (p < 0.001) and a lower NGTDM_Coarseness (p = 0.002) and sphericity (p = 0.010) than those without ACEs (Table 2).
The ML model was constructed using these top four features to prevent overfitting. Table 3 presents the diagnostic performance of each ML algorithm in the training and testing cohorts to predict ACEs.
In the training cohort, all ML algorithms achieved AUC values of > 0.80 for predicting ACEs (range: 0.841–0.944). Moreover, 5 of 7 ML algorithms (decision tree, RF, neural network, LR, and SVM) achieved F1 scores (range: 0.812–0.875), precision (range: 0.817–0.886), recall (range: 0.813–0.875), and accuracy (range: 0.813–0.875) of > 0.80 for predicting ACEs.
In the testing cohort, RF and neural network algorithms had an AUC of > 0.80 for predicting ACEs. The classification performance of RF (AUC—training cohort: 0.935, testing cohort: 0.889) and neural network (AUC—training cohort: 0.944, testing cohort: 0.889) in the testing cohort was similar to that of the training cohort. Meanwhile, the performance of the remaining five ML algorithms was poorer in the testing cohort (AUCs: 0.667–0.778) than in the training cohort.
The diagnostic indices including sensitivity, specificity, PPV, NPV, accuracy, and AUC did not significantly differ among these seven ML algorithms (each, p > 0.05) (Supplemental Table 3). However, among the seven ML algorithms, RF had the highest diagnostic index (average over classes—AUC: 0.889, F1 score: 0.882, precision: 0.905, recall: 0.899, sensitivity: 66.7% [2/3], specificity: 100% [6/6], PPV: 100% [2/2], NPV: 85.7% [6/7], and accuracy: 88.9% [8/9]). Supplemental Fig. 1 shows the important features of RF calculated using the decrease in AUC. GLRLM_RLNU was the most important feature with the highest mean value (0.150) and had a higher contribution in the modeling process.
Figures 1 and 2 show the representative 18F-FDG-PET/CT images of patients with and without ACEs, respectively.
A 39-year-old female patient with cardiac sarcoidosis who developed ACEs (VT) after the immunosuppressive treatment with prednisolone. Pretreatment 18F-FDG-PET/CT scan [maximum intensity projection [MIP] (a), trans-axial (b), coronal (c), and sagittal (d)] images revealed 18F-FDG uptake in the sarcoidosis lesions of the lymph nodes (supra clavicular, hilar, and mediastinal region). The yellow line represents the border of the volume of interest in the myocardium (SUVmax 11.3 g/mL, SUVmean 6.1 g/mL, CMV 29.7 mL, and CMA 180.9 g). Thereafter, the immunosuppressive treatment with prednisolone was initiated. The ACE (VT) occurred 25 months after pretreatment 18F-FDG-PET/CT scan at a maintenance prednisolone dose of 10 mg/day. The calculated probability score for predicting the risk of ACEs (positive ≥ 0.5) was 0.90 on RF. Thus, the ML model with RF algorithm can predict the risk of ACEs in this case
An 81-year-old male patient with cardiac sarcoidosis who did not develop ACEs after the immunosuppressive treatment with prednisolone. Pretreatment 18F-FDG-PET/CT scan [maximum intensity projection (MIP) (a), trans-axial (b), coronal (c), and sagittal (d)] images revealed 18F-FDG uptake in the sarcoidosis lesions of lymph nodes (hilar, and mediastinal region) and myocardium. The yellow line represents the border of the volume of interest in the myocardium (SUVmax 5.7 g/mL, SUVmean 4.0 g/mL, CMV 28.6 mL, and CMA 115.1 g). Thereafter, the immunosuppressive treatment with prednisolone was initiated. The ACE did not occur 30 months after pretreatment 18F-FDG-PET/CT scan at a maintenance prednisolone dose of 10 mg/day. The calculated probability score for predicting the risk of ACEs (positive ≥ 0.5) was 0 on RF. Thus, the ML model with the RF algorithm can predict the absence of ACE risk in this case
Discussion
The current study evaluated the usefulness of the ML approach using pretreatment 18F-FDG-PET-based radiomic features and the visibility of RV 18F-FDG uptake for predicting ACEs in patients with CS. RF had the best performance for predicting ACEs, with the highest AUC and accuracy among all ML algorithms. GLRLM_RLNU had the highest contribution in the modeling process of RF. Therefore, ML analyses using 18F-FDG-PET-based radiomic features may be useful for predicting the risk of ACEs in patients with CS.
Previous studies have examined the characteristics of 18F-FDG-PET/CT radiomic features in CS. Manabe et al. [10] evaluated the diagnostic value of 18F-FDG-PET/CT texture analysis in patients with CS. Results showed that GLRLM long-run emphasis and GLRLM short-run low gray level emphasis were significant independent predictors of CS diagnosis. Moreover, their group examined the efficacy of 18F-FDG-PET/CT texture analysis on providing prognostic information on patients with CS. Moreover, they reported that GLRLM high gray level run emphasis was significantly associated with ACEs [11].
In our study, patients with CS who developed ACEs had a significantly higher surface area, GLRLM_RLNU, and a lower NGTDM_Coarseness and sphericity than those who did not. GLRLM_RLNU is one of the higher order texture features, and it measures differences between the lengths of runs. The high GLRLM_RLNU values are indicative of heterogeneous images [37]. Coarseness, which is one of the NGTDMs, is associated with granularity within an image and is related to the level of special rate of change in intensity. The heterogeneous images had a high rate of change in the gray level within a neighborhood, which results in a low coarseness value [38, 39]. Surface area represents the area of the surface encompassing the VOI and has a direct relationship with spiculatedness [40]. The sphericity represents the degree to which the VOI is similar to a sphere (formula of calculation of sphericity was presented in the Supplemental Material), and sphericity increases as the shape of VOI more closely resembles that of a sphere [41]. Thus, ACEs may occur in patients with CS as evidenced by a more heterogeneous and larger myocardial 18F-FDG uptake, and higher asphericity.
Recently, the potential applications of ML analysis have been reported in the field of nuclear cardiology [12,13,14]. Hu et al. [12] examined the usefulness of ML models for predicting early coronary revascularization after single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). Results showed that the ML model outperformed the expert interpretation of MPI by nuclear cardiologists for predicting early revascularization performance. Rios et al. [13] showed that the ML models using automatically extracted variables had a better prognostic accuracy for major cardiac ACEs compared with standard interpretation in patients undergoing SPECT MPI. However, to the best of our knowledge, no study has previously investigated the efficacy of 18F-FDG-PET-based radiomics and the visibility of RV 18F-FDG uptake using the ML approach for predicting ACEs in patients with CS.
In our study, to prevent the influence of overfitting, the ML models were constructed using the top four features ranked by the decrease in Gini impurity to predict ACEs. In the training cohort, all seven ML algorithms had a good classification performance with AUC values of > 0.80. However, in the testing cohort, only two algorithms with RF and neural network algorithm achieved AUC values of > 0.80. Meanwhile, the performance of the remaining five ML algorithms (decision tree, kNN, Naïve Bayes, LR, and SVM) was poorer in the testing cohort (AUCs of 0.667–0.778) than in the training cohort probably due to overfitting. Although neither the AUC nor accuracy significantly differed among the seven ML algorithms, RF was the best performing classifier as it had the highest diagnostic accuracy (88.9% [8/9]). Moreover, it exhibited a similar classification performance between the training and testing cohorts (AUC: 0.935 vs 0.889). GLRLM_RLNU was the most important feature for the ML modeling process of RF. Hence, the ML model with RF algorithm using 18F-FDG-PET-based radiomic features and the visibility of RV 18F-FDG uptake can potentially predict ACEs in patients with CS.
It has been reported that 18F-FDG accumulation in the RV is associated with the ACEs [25, 42]. In our study, the complication rate of ACEs was significantly higher in patients with positive RV 18F-FDG uptake than that of patients with negative RV 18F-FDG uptake (85.7% [6/7] vs. 27.5% [11/40], p = 0.006). Thus, this finding was compatible with the previous reports [25, 42]. However, the visibility of RV 18F-FDG uptake was not ranked within top four features, and the constructed each ML model was not influenced by the visibility of RV 18F-FDG uptake.
This study had several limitations. First, it was retrospective in nature, and it had a relatively small study cohort with conducting only in a single institution. Thus, it is necessary to perform a multicenter prospective study with a significantly larger population to validate and confirm our findings. Second, using different PET/CT scanners might have affected the results of 18F-FDG-PET-based radiomic analyses. However, the post-reconstruction harmonization using ComBat was conducted during analyses to overcome this issue. Third, only 49 radiomic features extracted from the LIFEx software were used in ML analyses. However, the LIFEx software has been widely used for radiomic analyses in the field of PET/CT scan studies [43, 44]. Fourth, only seven ML algorithms (specifically decision tree, RF, neural network, kNN, Naïve Bayes, logistic regression, and SVM) were applied in the ML analyses. Nevertheless, we only used the ML algorithms implemented in the Orange software, which is a popular open-source tool that provides a visual approach to ML for an interactive data analysis, thereby facilitating the easy construction and configuration of workflows for ML studies [35]. Finally, although training and testing validation had a good classification performance, a training–test scheme with a larger population might be preferred for model validation.
In conclusion, ML analyses using 18F-FDG-PET-based radiomic features can be useful for predicting ACEs in patients with CS.
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Nakajo, M., Hirahara, D., Jinguji, M. et al. Machine learning approach using 18F-FDG-PET-radiomic features and the visibility of right ventricle 18F-FDG uptake for predicting clinical events in patients with cardiac sarcoidosis. Jpn J Radiol 42, 744–752 (2024). https://doi.org/10.1007/s11604-024-01546-y
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DOI: https://doi.org/10.1007/s11604-024-01546-y