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Reviewing applications of structural and functional MRI for bipolar disorder

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Abstract

Bipolar disorders (BDs) represent one of the leading causes of disability and morbidity globally. The use of functional magnetic resonance imaging (fMRI) is being increasingly studied as a tool to improve the diagnosis and treatment of BDs. While morphological biomarkers can be identified through the use of structural magnetic resonance imaging (sMRI), recent studies have demonstrated that varying degrees of both structural and functional impairments indicate differing bipolar subtypes. Within fMRI, resting-state fMRI has specifically drawn increased interest for its capability to detect different neuronal activation patterns compared to task-based fMRI. This study aims to review recently published literature regarding the use of fMRI to investigate structural–functional relationships in BD diagnosis and specifically resting-state fMRI to provide an opinion on fMRI’s modern clinical application. All sources in this literature review were collected through searches on both PubMed and Google Scholar databases for terms such as ‘resting-state fMRI’ and ‘functional neuroimaging biomarkers of bipolar disorder’. While there are promising results supporting the use of fMRI for improving differential accuracy and establishing clinically relevant biomarkers, additional evidence will be required before fMRI is considered a dependable component of the overall BD diagnostic process.

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Funding

This review was not funded.

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Authors and Affiliations

  1. Drexel University College of Medicine, 2900 W Queen Ln, Philadelphia, PA, 19129, USA

    Joseph Waller

  2. Sciences Department, UCLA Life, 612 Charles E Young Dr S, Los Angeles, CA, 90095, USA

    Tyler Miao

  3. Department of Biology, Baylor University, Waco, TX, 76706, USA

    Ifeoma Ikedionwu

  4. Mayo Clinic Alix School of Medicine, 13400 E. Shea Blvd., Scottsdale, AZ, 85259, USA

    Keldon K. Lin

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  1. Joseph Waller
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Correspondence to Joseph Waller.

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Waller, J., Miao, T., Ikedionwu, I. et al. Reviewing applications of structural and functional MRI for bipolar disorder. Jpn J Radiol 39, 414–423 (2021). https://doi.org/10.1007/s11604-020-01074-5

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