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T2*-weighted MR imaging findings of giant cell tumors of bone: radiological–pathological correlation

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Abstract

Purpose

To assess the correlation between T2*-weighted MR imaging and pathological findings of giant cell tumors (GCT) of bone.

Methods

Of the 33 patients with histopathologically proven GCT of bone, 12 were examined using 1.5-T MR imaging, including T2*-weighted imaging, and were included in this study. The imaging and pathological findings of GCTs were compared between GCTs with and without hypointensity on T2*-weighted images (T2* hypointensity).

Results

T2* hypointensity was observed in 6 out of 12 (50%) GCTs. Septal formation (83% vs. 17%; p < 0.05) and cystic formation (67% vs. 0%; p < 0.05) on T2-weighted images was significantly more frequent in the GCTs with T2* hypointensity compared with those without T2* hypointensity. Among the six GCTs with T2* hypointensity, a large amount of hemosiderin deposition was pathologically observed in five (83%) cases, whereas small amounts of hemosiderin deposition was seen in one (17%) case. In contrast, among the six GCTs without T2* hypointensity, a small amount of hemosiderin deposition was pathologically observed in all six (100%).

Conclusion

Half of the GCTs showed T2* hypointensity, which is characteristic of hemosiderin deposition; whereas, the other half did not show T2* hypointensity due to a small amount of hemosiderin deposition.

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Authors and Affiliations

  1. Department of Radiology, Kizawa Memorial Hospital, 590 Shimokobi, Kobi-cho, Minokamo City, Gifu, 505-8503, Japan

    Hironori Nishibori

  2. Department of Radiology, Gifu University School of Medicine, 1-1 Yanagido, Gifu, 501-1194, Japan

    Hiroki Kato, Masaya Kawaguchi & Masayuki Matsuo

  3. Department of Orthopedic Surgery, Gifu University School of Medicine, Gifu, Japan

    Akihito Nagano

Authors
  1. Hironori Nishibori
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  2. Hiroki Kato
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  3. Masaya Kawaguchi
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  4. Akihito Nagano
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  5. Masayuki Matsuo
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Correspondence to Hiroki Kato.

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Nishibori, H., Kato, H., Kawaguchi, M. et al. T2*-weighted MR imaging findings of giant cell tumors of bone: radiological–pathological correlation. Jpn J Radiol 37, 473–480 (2019). https://doi.org/10.1007/s11604-019-00829-z

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  • DOI: https://doi.org/10.1007/s11604-019-00829-z

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