Abstract
Purpose
The aim of this study was to compare prospectively the image quality of magnetic resonance cholangiopancreatography (MRCP) using manganese chloride tetrahydrate (Bothdel Oral Solution 10) (MCT), a new negative oral contrast agent; ferric ammonium citrate (FerriSeltz powder 20%) (FAC); and no agent.
Materials and methods
MRCP images (TE 970 ms) of patients administered MCT (n = 19) or FAC (n = 20) at random, and 18 patients without an agent were evaluated. The subjective image quality of the overall, extrahepatic bile duct, and pancreatic duct and the degree of elimination of gastrointestinal fluid scored by two radiologists blinded to information regarding the agent were compared using Mann-Whitney’s U-test.
Results
The degrees of elimination of gastroduodenal fluid of MCT and FAC were significantly better than those without an agent (P < 0.01 and P < 0.01). The subjective image quality of MCT of the overall and extrahepatic bile duct were significantly better, although no significant differences for FAC were observed compared with those without an agent (P < 0.01 and P = 0.21, P = 0.02 and P = 0.16). There were no significant differences for the pancreatic duct (P = 0.12 and P = 0.19), nor were there any significant differences in the evaluations between MCT and FAC (P = 0.19–0.98).
Conclusion
MCT has shown performance comparable to that of conventional FAC in terms of pancreatic and biliary depiction and safety.
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References
Taylor AC, Little AF, Hennessy OF, Banting SW, Smith PJ, Desmond PV. Prospective assessment of magnetic resonance cholangiopancreatography for noninvasive imaging of the biliary tree. Gastrointest Endosc 2002;55:17–22.
Limanond P, Raman SS, Ghobrial RM, Busuttil RW, Lu DS. The utility of MRCP in preoperative mapping of biliary anatomy in adult-to-adult living related liver transplant donors. J Magn Reson Imaging 2004;19:209–215.
Riordan RD, Khonsari M, Jeffries J, Maskell GF, Cook PG. Pineapple juice as a negative oral contrast agent in magnetic resonance cholangiopancreatography: a preliminary evaluation. Br J Radiol 2004;77:991–999.
Hirohashi S, Hirohashi R, Uchida H, Kitano S, Ono W, Ohishi H, et al. MR cholangiopancreatography and MR urography: improved enhancement with a negative oral contrast agent. Radiology 1997;203:281–285.
Wang YX, Hussain SM, Krestin GP. Superparamagnetic iron oxide contrast agents: physicochemical characteristics and applications in MR imaging. Eur Radiol 2001;11:2319–2331.
Takahara T, Saeki M, Nosaka S, Shimoyamada K, Suemitsu I, Nakajima Y, et al. The use of high concentration ferric ammonium citrate (FAC) solution as a negative bowel contrast agent: application in MR cholangiography. Nippon Igaku Hoshasen Gakkai Zasshi 1995;55:697–699.
Lecesne R, Drouillard J, Cissé R, Schiratti M. Contribution of Abdoscan in MRI cholangio-pancreatography and MRI urography. J Radiol 1998;79:573–575.
Obenauer S, Fischer U, Heuser M, Wilke R, Grabbe E. The optimization of MR cholangiopancreatography. Rofo 1999;171:450–454.
Petersein J, Reisinger W, Mutze S, Hamm B. Value of negative oral contrast media in MR cholangiopancreatography (MRCP). Rofo 2000;172:55–60.
Takahara T, Kurihara Y, Takahashi M, Nakajima Y, Ishikawa T. Clinical efficacy of suppression and visualization of the duodenal fluid in MR cholangiopancreatography using ferric ammonium citrate. Nippon Rinsho 1998;56:2865–2869.
Hirohashi S, Uchida H, Yoshikawa K, Fujita N, Ohtomo K, Yuasa Y, et al. Large scale clinical evaluation of bowel contrast agent containing ferric ammonium citrate in MRI. Magn Reson Imaging 1994;12:837–846.
Fujita O, Hiraishi K, Suginobu Y, Takeuchi M, Narabayashi I. Fundamental studies of oral contrast agents for MR: comparison of manganese agent and iron agent. Nippon Hoshasen Gijutsu Gakkai Zasshi 1996;52:1613–1618.
Hasegawa H, Fujita O, Hiraishi K, Narabayashi I, Komba T, Hamamura Y. Research on a new oral contrast agent for abdominal MRI using free manganese ion. Nippon Hoshasen Gijutsu Gakkai Zasshi 1996;52:1627–1632.
Hiraishi K, Narabayashi I, Fujita O, Yamamoto K, Sagami A, Hisada Y, et al. Blueberry juice: preliminary evaluation as an oral contrast agent in gastrointestinal MR imaging. Radiology 1995;194:119–123.
Takahashi T, Kato K, Nishizawa T, Nakazawa Y. Elimination of bowel fluid artifact on abdominal DWI using oral contrast agent ferric ammonium citrate. Nippon Hoshasen Gijutsu Gakkai Zasshi 2008;64:573–578.
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Morita, S., Ueno, E., Masukawa, A. et al. Prospective comparative study of negative oral contrast agents for magnetic resonance cholangiopancreatography. Jpn J Radiol 28, 117–122 (2010). https://doi.org/10.1007/s11604-009-0395-3
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DOI: https://doi.org/10.1007/s11604-009-0395-3