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Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases

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Abstract

Circular RNAs (circRNAs) are a class of regulatory non-coding RNAs characterized by the presence of covalently closed ends. A growing body of evidence suggests that circRNAs play important roles in physiology and pathology. In particular, accumulating data on circRNA functions in various central nervous system (CNS) diseases and their correlations indicate that circRNAs are critical contributors to the onset and development of brain disorders. In this review, we focus on the regulatory and functional roles of circRNAs in CNS diseases, highlighting their diagnostic and therapeutic potential, with the aim of providing new insights into CNS diseases.

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Authors and Affiliations

  1. Jiangsu Provincial Key Laboratory of Critical Care Medicine, Department of Pharmacology, School of Medicine, Southeast University, Nanjing, 210009, China

    Ying Bai & Hong-hong Yao

  2. Co-innovation Center of Neuroregeneration, Nantong University, Nantong, 226001, China

    Hong-hong Yao

  3. Institute of Life Sciences, Key Laboratory of Developmental Genes and Human Disease, Southeast University, Nanjing, 210009, China

    Hong-hong Yao

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  1. Ying Bai
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Correspondence to Hong-hong Yao.

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This study was supported by grants from the Science and Technology Innovation 2030-Major Project of the Ministry of Science and Technology of China (No. 2021ZD0202904 and No. 2021ZD0202900), the National Natural Science Foundation of China (No. 82230115 and No. 82273914), the National Science Fund for Distinguished Young Scholars (No. 82025033), and the Jiangsu Provincial Key Laboratory of Critical Care Medicine (No. JSKLCCM-2022-02-008).

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Bai, Y., Yao, Hh. Circular RNAs: Diagnostic and Therapeutic Perspectives in CNS Diseases. CURR MED SCI 43, 879–889 (2023). https://doi.org/10.1007/s11596-023-2784-8

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