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Association of Urinary Strontium Levels with Pregnancy-induced Hypertension

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Summary

Pregnancy-induced hypertension (PIH), including gestational hypertension and preeclampsia, accounts for the majority of maternal and perinatal morbidity and mortality. Strontium (Sr) has been recently associated with preeclampsia in a small group of women; however, the role of Sr in PIH is not fully understood and warrants further investigation. In this study, we examined the association between urinary Sr levels and PIH, and assessed the effect of maternal age on the association. Urinary Sr concentrations were measured in 5423 pregnant women before delivery by inductively coupled plasma mass spectrometry (ICP-MS). Logistic regression analysis adjusting for potential confounders was applied to explore the association between Sr and PIH, and to evaluate the Sr-PIH relationship stratified by maternal age. Among the participants, 200 (3.83%) women were diagnosed with PIH. Compared with non-PIH women, women who developed PIH had lower urinary Sr concentrations (131.26 vs. 174.98 μg/L creatinine, P<0.01). With the natural log-transformed urinary creatinine-standardized Sr concentrations increasing, the risk of PIH decreased significantly [adjusted OR=0.60 (95%CI: 0.51, 0.72)]. Furthermore, the significant association of Sr with PIH was found among women under 35 years (P<0.01). Our finding suggested that Sr may play a potential protective role in the pathogenesis of PIH, especially among young pregnant women under 35 years old.

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Acknowledgments

We thank all the mothers and their families who volunteered to participate in our study. We would also like to thank all the staff working in this project for their great effort and enthusiasm.

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Authors and Affiliations

  1. Key Laboratory of Environment and Health (HUST), Ministry of Education & Ministry of Environmental Protection, and State Key Laboratory of Environmental Health (Incubation), School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Yi Tang, Wei Xia, Shun-qing Xu, Hong-xiu Liu & Yuan-yuan Li

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  1. Yi Tang
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  2. Wei Xia
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Correspondence to Yuan-yuan Li.

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The authors declare that there is no conflict of interest with any financial organization or corporation or individual that can inappropriately influence this work. Author Shun-qing XU is a member of the Editorial Board for Current Medical Science. The paper was handled by the other editor and has undergone rigorous peer review process. Author Shun-qing XU was not involved in the journal’s review of, or decisions related to, this manuscript.

Additional information

This work was supported by the National Natural Science Foundation of China (No. 91743103) and Program for HUST Academic Frontier Youth Team (No. 2018QYTD12).

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Tang, Y., Xia, W., Xu, Sq. et al. Association of Urinary Strontium Levels with Pregnancy-induced Hypertension. CURR MED SCI 41, 535–541 (2021). https://doi.org/10.1007/s11596-021-2366-6

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  • DOI: https://doi.org/10.1007/s11596-021-2366-6

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