Summary
Caspase recruitment domain containing protein 9 (CARD9) is an adaptor protein that plays a critical role in pattern recognition receptors (PRRs)-mediated activation of NF-?B and mitogen-activated protein kinase (MAPK). This elicits initiation of the pro-inflammatory cytokines and leads to inflammatory responses, which has been recognized as a critical contributor to chronic inflammation. Current researches demonstrate that CARD9 is strongly associated with metabolic diseases, such as obesity, insulin resistance, atherosclerosis and so on. In this review, we summarize CARD9 signaling pathway and the role of CARD9 in metabolic diseases.
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17 July 2020
The article ���The Role of CARD9 in Metabolic Diseases���, written by Cheng TIAN, Ya-li TUO, Yi LU, Chuan-rui XU, Ming XIANG, was originally published electronically on the publisher���s internet portal on May 2020 without open access. With the author(s)��� decision to opt for Open Choice, the copyright of the article is changed to �� The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/), which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
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The original version of this article was revised due to a retrospective Open Access order.
This study was supported by the National Natural Science Foundation of China (No. 81872000).
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Tian, C., Tuo, Yl., Lu, Y. et al. The Role of CARD9 in Metabolic Diseases. CURR MED SCI 40, 199–205 (2020). https://doi.org/10.1007/s11596-020-2166-4
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DOI: https://doi.org/10.1007/s11596-020-2166-4