Skip to main content
SpringerLink
Log in

Effect of ethanol extract of Rhodiola rosea on the early nephropathy in type 2 diabetic rats

  • Published:
Journal of Huazhong University of Science and Technology [Medical Sciences] Aims and scope Submit manuscript

Summary

This study aimed to investigate the therapeutical effects of Rhodiola rosea extract on rats with type 2 diabetic nephropathy (DN). The rat type 2 DN model was established by high fat and high calorie feeding and intravenous injection of streptozocin (STZ). Wistar rats were randomly divided into normal group, control group, low dose Rhodiola rosea group, high dose Rhodiola rosea group and Captopril group. Oral glucose tolerance test (OGTT) was performed to determine the impairment of glucose tolerance in the established animal model. A series of parameters including fasting blood glucose (FBG), total cholesterol (TC), triglyceride (TG), creatinine clearance rate (Ccr), 24-h urinary albumin (UA), the ratio of kidney mass/body weight (renal index) and glomerular area were examined after 8 weeks. Moreover, the expression of transforming growth factor (TGF)-β1 in renal tissues was detected by using immunohistochemisty. At the end of the eighth week, FBG, TC, TG, Ccr, 24-h urinary albumin, the ratio of kidney mass/body weight and glomerular area were significantly reduced in Rhodiola rosea extract treatment groups as compared with those in control group. TGF-β1 expression in renal tissues of Rhodiola rosea extract treatment groups was also significantly decreased as compared with that of control group. These results indicate that Rhodiola rosea extract may have a protective effect on early nephropathy in diabetic rats, which might be related to the decrease of the renal expression of TGF-β1.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Fornoni A, Ijaz A, Tejada T, et al. Role of inflammation indiabetic nephropathy. Curr Diabetes Rev, 2008,4(1): 10–17

    Article  PubMed  CAS  Google Scholar 

  2. Qian EW, Ge DT, Kong SK. Salidroside promotes erythropoiesis and protects erythroblasts against oxidative stress by up-regulating glutathione peroxidase and thioredoxin. J Ethnopharmacol, 2011,133(2):308–314

    Article  PubMed  CAS  Google Scholar 

  3. Zhu J, Wan X, Zhu Y, et al. Evaluation of salidroside in vitro and in vivo genotoxicity. Drug Chem Toxicol, 2010,33(2):220–226

    Article  PubMed  CAS  Google Scholar 

  4. Hu X, Lin S, Yu D, et al. A preliminary study: the anti-proliferation effect of salidroside on different human cancer cell lines. Cell Biol Toxicol, 2010,26(6):499–507

    Article  PubMed  CAS  Google Scholar 

  5. Zhang Z, Liu J, Shang X, et al. The effect of Rhodiola capsules on oxygen consumption of myocardium and coronary artery blood flow in dogs. Zhongguo Zhong Yao Za Zhi (Chinese), 1998,23(2):104–106

    CAS  Google Scholar 

  6. Jin XN, Song BH, Jia YJ, et al. Protective effects of the ethanol extract of Rhodiola rosea on blood glucose and structural changes of kidney in streptozotocin-induced diabetic rats. Yanbian Daxue Yixue Xuebao (Chinese), 2009,32(4):241–243

    Google Scholar 

  7. Liu YY, Mao L, Mo QZ. Experimental NIDDM rat model. Zhonghua Neifenmi Daixie Zazhi (Chinese), 1990,6(2): 115

    CAS  Google Scholar 

  8. Guo XH, Liu ZH, Li H, et al. Type 2 diabetes mellitus induced by diets and its features of renal involvement in rat. Zhongguo Tangniaobing Zazhi (Chinese), 2002,10(5): 291

    Google Scholar 

  9. Caramori MLA, Mauer M. Diabetes and nephropathy. Curr Opin Nephrol Hypertens, 2003,12(3):273–282

    Article  PubMed  CAS  Google Scholar 

  10. Lin ST. Diabetic nephropathy. Zhonghua Zhongxiyi Jiehe Zazhi (Chinese), 2005,14(3):229–230

    Google Scholar 

  11. Koves TR, Ussher JR, Noland RC, et al. Mitochondrial overload and incomplete fatty acid oxidation contribute to skeletal muscle insulin resistance. Cell Metab, 2008,7(1): 45–56

    Article  PubMed  CAS  Google Scholar 

  12. Roberts AB, McCune BK, Sporn MB. TGF-beta: regulation of extracellular matrix. Kidney Int, 1992,41(3): 557–559

    Article  PubMed  CAS  Google Scholar 

  13. Gould SE, Day M, Jones SS, et al. BMP-7 regulates chemokine, cytokine, and hemodynamic gene expression in proximal tubule cells. Kidney Int, 2002,61(1):51–60

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Institute of Integrative Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Zhi-sen Wang  (王智森), Fei Gao  (高 飞) & Fu-er Lu  (陆付耳)

  2. Shijiazhuang Zangnuo Bio-Tech Co., Ltd., Shijiazhuang, 050035, China

    Zhi-sen Wang  (王智森) & Fei Gao  (高 飞)

Authors
  1. Zhi-sen Wang  (王智森)
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Fei Gao  (高 飞)
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Fu-er Lu  (陆付耳)
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Fu-er Lu  (陆付耳).

Additional information

This project was supported by the National Natural Science Foundation of China (No. 30772853).

Rights and permissions

Reprints and permissions

About this article

Cite this article

Wang, Zs., Gao, F. & Lu, Fe. Effect of ethanol extract of Rhodiola rosea on the early nephropathy in type 2 diabetic rats. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 33, 375–378 (2013). https://doi.org/10.1007/s11596-013-1127-6

Download citation

  • Received:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11596-013-1127-6

Key words

Search

Navigation