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Implication of expression of osteopontin and its receptor integrin ανβ3 in the placenta in the development of preeclampsia

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Summary

To investigate the expression of osteopontin (OPN) and its receptor integrin ανβ3 in the placental tissue from pregnant women complicated with preeclampsia, the expression of OPN and ανβ3 in the placenta of the pregnant women with preeclampsia and healthy pregnant women was detected by immunohistochemistry, Western blotting and RT-PCR. Our results showed that OPN and ανβ3 protein were expressed in the placenta from normal pregnant woman and those with preeclampsia. OPN was located in the placental syncytiotrophoblasts and the cytoplasm of capillary endothelial cells and integrin ανβ3 was mainly expressed on the surface of trophoblast cells. Expression of OPN and integrin ανβ3 in the placental tissue from preeclampsia subjects was significantly lower than that from the control group (P<0.05). Compared with the control group, expression of OPN in the placental tissue from preeclampsia group was significantly lower (P<0.05) but there was no significant difference in the expression of αν and β3 between the preeclampsia group and the controls. It is concluded that OPN and its receptor integrin ανβ3 may be involved in the pathogenesis of preeclampsia.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China

    Junxia Xia  (夏俊霞), Fuyuan Qiao  (乔福元) & Haiyi Liu  (刘海意)

  2. Department of Obstetrics, Shenzhen People’s Hospital, the Second Clinical Medical College of Jinan University, Shenzhen, 518020, China

    Junxia Xia  (夏俊霞) & Fangmin Su  (苏放明)

Authors
  1. Junxia Xia  (夏俊霞)
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  2. Fuyuan Qiao  (乔福元)
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  3. Fangmin Su  (苏放明)
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  4. Haiyi Liu  (刘海意)
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Additional information

This project was supported by a grant from Shenzhen Municipal Science and Technology Program (No. 200802107) and a grant for medical research programs from the Health Department of Guangdong Province (No. A2009593).

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Xia, J., Qiao, F., Su, F. et al. Implication of expression of osteopontin and its receptor integrin ανβ3 in the placenta in the development of preeclampsia. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 755–760 (2009). https://doi.org/10.1007/s11596-009-0617-z

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  • DOI: https://doi.org/10.1007/s11596-009-0617-z

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