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Expression of phosphorylated-STAT3 and osteopontin and their correlation in melanoma

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Summary

The expressions of p-STAT3 and osteopontin in 22 cases of normal nevi and 43 cases of malignant melanoma were immunohistochemically detected, and the correlation between p-STAT3 and osteopontin in malignant melanoma and the correlations of p-STAT3 (or osteopontin) with invasion, metastasis and thickness of malignant melanoma were examined. The results showed p-STAT3 was expressed in 2 of 22 cases of normal nevi and 30 of 43 cases of malignant melanoma, while osteopontin was expressed in 3 cases of normal nevi and 29 cases of malignant melanoma. The expressions of p-STAT3 and osteopontin in melanoma were significantly higher than that in benign nevi. There existed significant correlations between the expression of p-STAT3 and that of osteopontin in melanoma. Furthermore, the expression rates of p-STAT3 were significantly higher in invasive or metastatic melanomas than that their non-invasive or non-metastatic counterparts, and the expression rates of osteopontin were significantly higher in invasive melanomas than that in non-invasive ones. It is concluded that p-STAT3 and osteopontin may play important roles in the pathogenesis of malignant melanoma.

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Authors and Affiliations

  1. Department of Dermatology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China

    Yan Wu  (吴艳), Ping Jiang  (蒋苹), Yun Lin  (林云), Siyuan Chen  (陈思远), Nengxing Lin  (林能兴) & Jiawen Li  (李家文)

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  1. Yan Wu  (吴艳)
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  2. Ping Jiang  (蒋苹)
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  3. Yun Lin  (林云)
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  4. Siyuan Chen  (陈思远)
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  5. Nengxing Lin  (林能兴)
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  6. Jiawen Li  (李家文)
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The two authors contributed equally to the project.

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Wu, Y., Jiang, P., Lin, Y. et al. Expression of phosphorylated-STAT3 and osteopontin and their correlation in melanoma. J. Huazhong Univ. Sci. Technol. [Med. Sci.] 29, 246–250 (2009). https://doi.org/10.1007/s11596-009-0223-0

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  • DOI: https://doi.org/10.1007/s11596-009-0223-0

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