Summary
In order to study the effect of excessive iodine on immune function of lymphocytes and the role of selenium supplementation with excessive iodine intake, the changes of T lymphocyte number, ratio of subsets, activity of natural killer (NK) cells and lymphocytes proliferation response were investigated. 150 female BALB/C mice were randomly divided into 5 groups in terms of their body weight (n=30 in each group), and 10 of each group were taken as one batch for test. Mice in the 5 groups were orally administrated with iodine 0 (group I), 1500 (group II), 3000 (group III), 6000 μg/L (group IV), iodine 6000 μg/L plus selenium 0.3 mg/L (group V) respectively for 30 days Lymphocyte proliferation response, CD4+/CD8+, Th1/Th2 and the activity of NK cells were measured. CD4+/CD8+ was significantly lower, while lymphocyte proliferation response stronger, and Th1/Th2 and the activity of NK cells significantly higher in group IV than in group I (P<0.01). There was no significant difference in all indexes between group V and group I (P>0.05). It was suggested that excessive iodine as exogenous chemical materials can induce disorders of T lymphocyte immune function in mice. 0.3 mg/L selenium supplementation can protect mice against toxicity induced by 6000 μg/L iodine.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Allen E M, Appel M C, Braveman L E. The effect of iodine ingestion on the development of spontaneous lymphocytic thyroiditis in the diabetes-prone BB/W rat. Endocrinology, 1986,118:1977–1981
Li M, Eastman C J, Boyages S C. Iodine induced lymphocytic thyroiditis in the BB/W rat: early and late immune phenomena. Autoimmunity, 1993,14(3): 181–187
Many M C, Maniratunga S, Varis I et al. Two-step development of hashimoto-like thyroiditis in genetically autoimmune prone non-obese diabetic mice: effects of iodine-induced cell necrosis. Endocrinology, 1995,147:311–320
Laurberg P. Iodine intake-what are we aiming at?. Clin Endocrinol Metab, 1994,79: 17–19
Gao Q J, Liu Y, Xu C L et al. Study on dose-reaction relationship between different iodine dose and morphology and function of thyroid. Chin Public Health (Chinese), 2002,18:423–424
Zh X, Liu Y G, Toxicology. Bejing: Beijing Medical University & Chinese Xiehe Medical University Union Publishing House, 1997.5
Guo J, Rapoport B, Mclachlan S M. Balance of Th1/Th2 cytokines in thyroid autoantibody synthesis in vitro. Autoimmunity, 1999,30:1–9
O’shea J J, Ma A, Lipsky P. Cytokines and autoimmunity. Nat Rev Immunol, 2002,2:37–45
Xiang J M, Chen Z P, Di H J. Effects of excessive iodine on antioxidizing ability of mice. Chin J Endemiol (Chinese), 1999,18:245–249
Zeng J, Luo H J. Progress in trace elements and health selenic research. Studies Trace Elements Health (Chinese), 2003,2(2):52–56
Yang X F, Hou X H. Effects of excessive iodine on antioxidizing ability of mice and intervention with selenium. Chin Public Health (Chinese), 2004,20(9): 1081–1082
Author information
Authors and Affiliations
Corresponding author
Additional information
CHEN Xiaoyi, female, born in 1965, Associate Professor, M.D., Ph.D.
This project was supported by a grant from the National Natural Sciences Foundation of China (No. 30230330).
Rights and permissions
About this article
Cite this article
Chen, X., Liu, L., Yao, P. et al. Effect of excessive iodine on immune function of lymphocytes and intervention with selenium. J. Huazhong Univ. Sc. Technol. 27, 422–425 (2007). https://doi.org/10.1007/s11596-007-0418-1
Received:
Issue Date:
DOI: https://doi.org/10.1007/s11596-007-0418-1