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Cellulose-based polymeric liquid crystals as a biomimetic modifier for suppressing protein adsorption

  • Biomaterials
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Journal of Wuhan University of Technology-Mater. Sci. Ed. Aims and scope Submit manuscript

Abstract

A novel biomimetic protein-resistant modifier based on cellulose-based polymeric liquid crystals was described (PLCs). Two types of PLCs of propyl hydroxypropyl cellulose ester (PPC) and octyl hydroxypropyl cellulose ester (OPC) were prepared by esterification from hydroxypropyl cellulose, and then were mixed with polyvinyl chloride and polyurethane to obtain composite films by solution casting, respectively. The surface morphology of PLCs and their composite films were characterized by polarized optical microscopy (POM) and scanning electron microscopy (SEM), suggesting the existence of microdomain separation with fingerprint texture in PLC composite films. Water contact angle measurement results indicated that hydrophilicity of PLC/polymer composite films was dependent on the type and content of PLC as well as the type of matrix due to their interaction. Using bovine serum albumin (BSA) as a model protein, protein adsorption results revealed that PLCs with protein-resistant property can obviously suppress protein adsorption on their composite films, probably due to their flexible LC state. Moreover, all PLCs and their composites exhibited non-toxicity by MTT assay, suggesting their safety for biomedical applications.

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Authors and Affiliations

  1. College of Chinese and Culture, Jinan University, Guangzhou, 510632, China

    Fangmin Situ  (徒方民)

  2. Department of Materials Science and Engineering, College of Science and Engineering, Jinan University, Guangzhou, 510632, China

    Ruizhe Tan, Lei Gong, Mei Tu  (屠美) & Rong Zeng

  3. The First Affiliated Hospital, Jinan University, Guangzhou, 510632, China

    Zhengang Zha & Hao Wu

  4. School of medicine, Jinan University, Guangzhou, 510632, China

    Jiaqing Zhang

  5. Macau Medical Science & Technology Research Association, 999078, Macau, China

    Liheng Zheng

Authors
  1. Fangmin Situ  (徒方民)
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  2. Ruizhe Tan
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  3. Lei Gong
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  4. Zhengang Zha
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  5. Mei Tu  (屠美)
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  6. Rong Zeng
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  7. Hao Wu
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  8. Jiaqing Zhang
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  9. Liheng Zheng
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Corresponding author

Correspondence to Mei Tu  (屠美).

Additional information

Funded by the National Natural Science Foundation of China (Nos. 31170911 and 31040027), the Research Development and Innovation Fund of Jinan University (No. 21611410), the Open Fund of the First Affiliated Hospital, Jinan University, Guangzhou(No. 511005024) and the Macao Science and Technology Development Fund(No. 064/2013/A2)

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Situ, F., Tan, R., Gong, L. et al. Cellulose-based polymeric liquid crystals as a biomimetic modifier for suppressing protein adsorption. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 30, 416–422 (2015). https://doi.org/10.1007/s11595-015-1163-0

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  • DOI: https://doi.org/10.1007/s11595-015-1163-0

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