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Synthesis, characterization and antibacterial property of strontium half and totally substituted hydroxyapatite nanoparticles

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Abstract

Nanoparticles of hydroxyapatite(HAP), strontium half substituted hydroxyapatite (SrCaHAP) and strontium totally substituted hydroxyapatite (SrHAP) were prepared by sol-gel-supercritical fluid drying (SCFD) method. The nanoparticles were characterized by element content analysis, FT-IR, XRD and TEM, and the effects of strontium substitution on crystal structure, crystallinity, particle shape and antibacterial properties of the nanoparticles on Escherichia coli, Staphylococcus aureus, Lactobacillus were researched. Results show that strontium can half and totally substitute for calcium and enter the structure of apatite according to the initial atomic ratios of Sr/[Sr+Ca] as 0.5, 1. The substitution decreases the IR wavenumbers of SrCaHAP and SrHAP, and changes the morphology of the nanoparticles from short rod shaped HAP to needle shaped SrCaHAP, and back to short rod shaped SrHAP. The crystallinity of HAP is higher than that of SrCaHAP, but is lower than that of SrHAP. Moreover, the antibacterial property of SrCaHAP and SrHAP are improved after the calcium is half and totally substituted by strontium.

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References

  1. Y F WANG, Y H YAN, M J LI, et al. Influential Factors on Morphology of Hydroxyapatite Crystals[J]. Journal of Wuhan University of Technolog-Mater. Sci. Ed, 2003, 18(1):33–36

    Article  Google Scholar 

  2. Hideki, Aoki. Science and Medical Applications of Hydroxyapatite[J]. Japanese Association of Apatite Science, 1992:137–190

  3. Y J SONG, M S LI, Y P LV, et al. Analysis on the Difference between Synthetic Hydroxyapatite and Bone Apatite[J]. Journal of Wuhan University of Technology-Mater. Sci. Ed, 2005, 20(Suppl.):170–172

    CAS  Google Scholar 

  4. Y F FU, D M CHEN. Infl uence of Sr2+ on Strontium Substituted Hydroxyapatite’s (Sr-HA)[J]. J Oral Tissue Eng, 2005, 2(2):76–80

    Google Scholar 

  5. A Bigi, E Foresti, M Gandolfi, et al. Inhibiting Effect of Zinc on Hydroxylapatite Crystallization[J]. Journal of Inorganic Biochemistry, 1995, 58:49–58

    Article  CAS  Google Scholar 

  6. T N KIM, Q L FENG, J O KIM, et al. Antimicrobial Effects of Metals Ions in Hydroxyapatite[J]. Journal of Materials Science: Materials in Medicine, 1998, 9:129–134

    Article  Google Scholar 

  7. F Q DONG, G W LI, Z G SUN, et al. Preparation and Antimicrobial Ability of Natural Porous Antibacterial Materials[J]. J. Cent. South. Univ. Technol, 2005, 12(4):370–375

    Article  CAS  Google Scholar 

  8. D Gerlalia. Effects of Strontium and Fluoride Uptakes on the Solubility of Powdered Enamel[J]. Caries Res. 1997, 11(2): 287–292

    Google Scholar 

  9. K ZHAO, Q L FENG, G Q CHEN. Antibacterial Effects of Silver Loaded Hydroxyapatite[J]. Tsing Hua Science and Technology, 1999, 4(3):1570–1573

    CAS  Google Scholar 

  10. J Christoffersen, M R Christoffersen, N Kolthoff, et al. Effects of Strontium Ions on Growth and Dissolution of Hydroxyapatite and Bone Mineral Detection[J]. Bone, 1997, 20(1): 47–54

    Article  CAS  Google Scholar 

  11. D P LIAO, Z Y ZHOU, Y F GU. A Fundamental Study on Bioreactions of SrHA[J]. West China Journal of Stomatology, 2002, 20(3):172–174 (in Chinese)

    Google Scholar 

  12. D G GUO, K W XU, X Y ZHAO, et al. Development of a Strontium-containing Hydroxyapatite Bone Cement[J]. Biomaterials, 2005, 26:4073–4083

    Article  CAS  Google Scholar 

  13. Y M ZHANG, Q T WANG, T FU. Wet Synthesis and Structure Stability of Strontium-containing Hydroxyapatite[J]. Rare Metal Materials and Engineering, 2004, 33(10):1049–1051 (in Chinese)

    CAS  Google Scholar 

  14. H W KIM, Y H KOH, Y M KONG, et al. Strontium Substituted Calcium Phosphate Biphasic Ceramics Obtained by a Powder Precipitation Method[J]. Journal of Materials Science: Materials in Medicine, 2004, 15: 1129–1134

    Article  CAS  Google Scholar 

  15. Z Y LI, X D ZHANG, D P HU. Tunable Fluids and Green Chemical Processes. Chemistry, 2003, 66(5): 323–326 (in Chinese)

    CAS  Google Scholar 

  16. Z Y LI, Y LI, X W DING. Application of Supercritical Fluids in Micro-powder Formation[J]. Journal of Chemical Industry & Engineering, 2000, 21(4): 6–12 (in Chinese)

    Google Scholar 

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Authors and Affiliations

  1. College of Material Science and Engineering, South China University of Technology, Guangzhou, 510640, China

    Yingguang Lin  (林英光) & Lianshi Wang

  2. School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, 510640, China

    Yingguang Lin  (林英光), Zhuoru Yang & Jiang Cheng

Authors
  1. Yingguang Lin  (林英光)
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  2. Zhuoru Yang
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  3. Jiang Cheng
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  4. Lianshi Wang
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Correspondence to Yingguang Lin  (林英光).

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Lin, Y., Yang, Z., Cheng, J. et al. Synthesis, characterization and antibacterial property of strontium half and totally substituted hydroxyapatite nanoparticles. J. Wuhan Univ. Technol.-Mat. Sci. Edit. 23, 475–479 (2008). https://doi.org/10.1007/s11595-006-4475-2

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  • DOI: https://doi.org/10.1007/s11595-006-4475-2

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