Abstract
Purpose
Patient-specific musculoskeletal biomechanical simulation is useful in preoperative surgical planning and postoperative assessment in orthopedic surgery and rehabilitation medicine. A difficulty in application of the patient-specific musculoskeletal modeling comes from the fact that the muscle attachment regions are typically invisible in CT and MRI. Our purpose is to develop a method for estimating patient-specific muscle attachment regions from 3D medical images and to validate with cadaver experiments.
Methods
Eight fresh cadaver specimens of the lower extremity were used in the experiments. Before dissection, CT images of all the specimens were acquired and the bone regions in CT images were extracted using an automated segmentation method to reconstruct the bone shape models. During dissection, ten different muscle attachment regions were recorded with an optical motion tracker. Then, these regions obtained from eight cadavers were integrated on an average bone surface via non-rigid registration, and muscle attachment probabilistic atlases (PAs) were constructed. An average muscle attachment region derived from the PA was non-rigidly mapped to the patients bone surface to estimate the patient-specific muscle attachment region.
Results
Average Dice similarity coefficient between the true and estimated attachment areas computed by the proposed method was more than 10% higher than the one computed by a previous method in most cases and the average boundary distance error of the proposed method was 1.1 mm smaller than the previous method on average.
Conclusion
We conducted cadaver experiments to measure the attachment regions of the hip muscles and constructed PAs of the muscle attachment regions. The muscle attachment PA clarified the variations of the location of the muscle attachments and allowed us to estimate the patient-specific attachment area more accurately based on the patient bone shape derived from CT.
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Acknowledgements
This research was supported by MEXT/JSPS KAKENHI 26108004, JST PRESTO 20407, AMED/ETH the strategic Japanese-Swiss cooperative research program, and R21EB020113-01 from National Institutes of Health. The authors gratefully acknowledge the contributions of Drs. Ryan Murphy, Stephen Belkoff, Demetries Boston (Johns Hopkins University) to the cadaver experiments.
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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. The study has been approved by the Institutional Review Board of Osaka University Hospital (No. 15538) and Nara Institute of Science and Technology (No. 2016-I-20).
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Fukuda, N., Otake, Y., Takao, M. et al. Estimation of attachment regions of hip muscles in CT image using muscle attachment probabilistic atlas constructed from measurements in eight cadavers. Int J CARS 12, 733–742 (2017). https://doi.org/10.1007/s11548-016-1519-8
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DOI: https://doi.org/10.1007/s11548-016-1519-8