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Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer

  • Vascular And Interventional Radiology
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Abstract

Unresectable locally advanced pancreatic cancer with or without metastatic disease is associated with a very poor prognosis. Ablation techniques are based on direct application of chemical, thermal, or electrical energy to a tumor, which leads to cellular necrosis. Initial studies about ablation therapies of the pancreas were associated with significant morbidity and mortality, which limited widespread adoption. Modifications to the various applications, in particular combining the techniques with high-quality imaging and intra-operative approach has enabled real-time treatment monitoring and significant improvements in safety. Inoperable cases of pancreatic cancer have been treated by various ablation techniques in the last few years with promising results. The purpose of this review is to present the current status of local ablative therapies in the treatment of pancreatic advanced tumor.

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Conflict of interest

The Authors declare no conflict of interest.

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Authors and Affiliations

  1. Department of Radiology, Interventional Radiology, Insubria University, Viale Borri, 57, 21100, Varese, Italy

    Anna Maria Ierardi, Natalie Lucchina, Chiara Floridi, Filippo Piacentino, Federico Fontana, Carlo Fugazzola & Gianpaolo Carrafiello

  2. Department of Radiology, Second University of Naples, Piazza Miraglia 9, 80134, Naples, Italy

    Mario Petrillo

  3. Anaesthesia and Palliative Care, University of Insubria, Ospedale di Circolo e Fondazione Macchi, Viale Borri 57, 21100, Varese, VA, Italy

    Alessandro Bacuzzi

  4. Institute of Radiology, University of Turin, Turin, TO, Italy

    Paolo Fonio

  5. Department of Radiology, Università degli Studi del Molise, Campobasso, Italy

    Luca Brunese

Authors
  1. Anna Maria Ierardi
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  2. Natalie Lucchina
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  3. Mario Petrillo
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  4. Chiara Floridi
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  5. Filippo Piacentino
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  6. Alessandro Bacuzzi
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  7. Paolo Fonio
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  8. Federico Fontana
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  9. Carlo Fugazzola
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  10. Luca Brunese
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  11. Gianpaolo Carrafiello
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Correspondence to Gianpaolo Carrafiello.

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Ierardi, A.M., Lucchina, N., Petrillo, M. et al. Systematic review of minimally invasive ablation treatment for locally advanced pancreatic cancer. Radiol med 119, 483–498 (2014). https://doi.org/10.1007/s11547-014-0417-9

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  • DOI: https://doi.org/10.1007/s11547-014-0417-9

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