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A novel and reliable computational intelligence system for breast cancer detection


Cancer is the second important morbidity and mortality factor among women and the most incident type is breast cancer. This paper suggests a hybrid computational intelligence model based on unsupervised and supervised learning techniques, i.e., self-organizing map (SOM) and complex-valued neural network (CVNN), for reliable detection of breast cancer. The dataset used in this paper consists of 822 patients with five features (patient’s breast mass shape, margin, density, patient’s age, and Breast Imaging Reporting and Data System assessment). The proposed model was used for the first time and can be categorized in two stages. In the first stage, considering the input features, SOM technique was used to cluster the patients with the most similarity. Then, in the second stage, for each cluster, the patient’s features were applied to complex-valued neural network and dealt with to classify breast cancer severity (benign or malign). The obtained results corresponding to each patient were compared to the medical diagnosis results using receiver operating characteristic analyses and confusion matrix. In the testing phase, health and disease detection ratios were 94 and 95%, respectively. Accordingly, the superiority of the proposed model was proved and can be used for reliable and robust detection of breast cancer.

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The authors would like to specially thank the anonymous reviewers for their valuable comments and suggestions to improve the quality of the article.


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Correspondence to Amin Zadeh Shirazi.

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Zadeh Shirazi, A., Seyyed Mahdavi Chabok, S.J. & Mohammadi, Z. A novel and reliable computational intelligence system for breast cancer detection. Med Biol Eng Comput 56, 721–732 (2018).

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  • Medical computing
  • Breast cancer
  • Medical diagnosis
  • Computational intelligence
  • Complex neural network
  • SOM