Skip to main content

Advertisement

Log in

Prediction of Breast Cancer Using Artificial Neural Networks

  • ORIGINAL PAPER
  • Published:
Journal of Medical Systems Aims and scope Submit manuscript

Abstract

In this study, an artificial neural network (ANN) was developed to determine whether patients have breast cancer or not. Whether patients have cancer or not and if they have its type can be determined by using ANN and BI-RADS evaluation and based on the age of the patient, mass shape, mass border and mass density. Though this system cannot diagnose cancer conclusively, it helps physicians in deciding whether a biopsy is required by providing information about whether the patient has breast cancer or not. Data obtained from 800 patients who were diagnosed with cancer definitively through biopsy. The definitive diagnosis corresponding to each patient and the data from ANN model results were investigated using Confusion matrix and ROC analyses. In the test data of the ANN model that was implemented as a result of these analyses, disease prediction rate was 90.5% and the health ratio was 80.9%. It is seen from these high predictive values that the ANN model is fast, reliable and without any risks and therefore can be of great help to physicians.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Firat, D., and Hayran, M., Cancer Statistics in Turkey and in the World (1990–1992). Turkish Association for Cancer Research and Control. İz Press, Ankara, 1995.

    Google Scholar 

  2. Şengelen, M., Kutluk, T., and Fırat, D., Cancer statistics in Turkey and in the World (1996–2003). Turkish Association for Cancer Research and Control. İz Press, Ankara, 2007.

    Google Scholar 

  3. Stomper PC, Connolly JC, Meyer JE, et al. (1989) Clinically occult ductal carcinoma in-situ detected with mammography: Analysis of 100 cases with radiologic-pathologic correlation. Radiology 172–235

  4. Holland, R., Ductal carcinoma in situ (DCIS). Eur. Radiol. 10:327–330, 2000.

    Google Scholar 

  5. American College of Radiology, Breast imaging reporting and data system (BI-RADS), 3rd edition. American College of the Radiology, Reston, VA, 1998.

    Google Scholar 

  6. Erkul, Z. K., Erkuş, M., Taşkın, F., and Meteoğlu, İ., Liesegang ring calcification in breast biopsy: case report. J. Breast Healthy. 1(1):22–24, 2005.

    Google Scholar 

  7. Gülsün, M., Demirkazık, F. B., Köksal, A., and Arıyürek, M., According to BI-RADS assessment of breast microcalcifications and to investigate the agreement between reviewers. Off. J. Turkish Soc. Radiol. 8(3):358–363, 2002.

    Google Scholar 

  8. Renee, W., Pinsky, M. D., Mark, A., and Helvie, M. D., Medscape mammographic breast density: Effect on imaging and breast cancer risk: Breast density measurement. JNCCN-J. Natl. Compr. Cancer Netw. 8:1157–1165, 2010.

    Google Scholar 

  9. Edward, T. B., Rick, K., and Robert, R., Conn’s current therapy. Elsevier INC, Saunders, Philadelphia, 2011.

    Google Scholar 

  10. Elter, M., Schulz-Wendtland, R., and Wittenberg, T., The prediction of breast cancer biopsy outcomes using two CAD approaches that both emphasize an intelligible decision process. Med. Phys. 34(11):4164–4172, 2007.

    Article  Google Scholar 

  11. Nassif, H., Page, D., Ayvaci, M., Shavlik, J., and Burnside, E. S., Uncovering age-specific invasive and DCIS breast cancer rules using inductive logic programming. In: Veinot, T. (Ed.), Proceedings of the 1st ACM International Health Informatics Symposium (IHI ‘10). ACM, New York, pp. 76–82, 2010.

    Google Scholar 

  12. American College of Radiology, Breast imaging reporting and data system (BI-RADS), 4th edition. American College of Radiology, Reston, VA, 2003.

    Google Scholar 

  13. Baker, J. A., Kornguth, P. J., Lo, J. Y., Williford, M. E., and Floyd, C. E., Breast cancer: Prediction with artificial neural network based on BI-RADS standardized lexicon. Radiology 196:817–822, 1995.

    Google Scholar 

  14. Markey, M. K., Lo, J. Y., Vargas-Voracek, R., Tourassi, G. D., and Floyd, C. E., Perception error surface analysis: A case study in breast cancer diagnosis. Comput. Biol. Med. 32:99–109, 2002.

    Article  Google Scholar 

  15. Floyd, C. E., Lo, J. Y., and Tourassi, G. D., Case-based reasoning computer algorithm that uses mammographic findings for breast biopsy decisions, AJR. Am. J. Roentgenol. 175:1347–1352, 2000.

    Google Scholar 

  16. Bilska-Wolak, A. O., and Floyd, C. E., Investigating different similarity measures for a case-based reasoning classifier to predict breast cancer. Proc SPIE 4322:1862–1866, 2001.

    Article  Google Scholar 

  17. Bilska-Wolak, A. O., and Floyd, C. E., Development and evaluation of a case-based reasoning classifier for prediction of breast biopsy outcome with BI-RADS lexicon. Med. Phys. 29:2090–2100, 2002.

    Article  Google Scholar 

  18. Bilska-Wolak, A. O., Floyd, C. E., Lo, J. Y., and Baker, J. A., Computer aid for decision to biopsy breast masses on mammography: Validation on new cases. Acad. Radiol. 12:671–680, 2005.

    Article  Google Scholar 

  19. Markey, M. K., Fischer, E. A., and Lo, J. Y. Bayesian networks of BIRADS descriptors for breast lesion classifications. International Conference of the IEEE Engineering in Medicine and Biology Society. San Francisco, California 3031–3034, 2004

  20. UCI Machine Learning Repository: Data Sets 2007. http://archive.ics.uci.edu/ml/datasets/Mammographic+Mass, Accessed 29 March 2011

  21. Saritas, I., Ozkan, I. A., and Sert, I. U., Prognosis of prostate cancer by artificial neural networks. Expert Syst. Appl. 37(9):6646–6650, 2010.

    Article  Google Scholar 

  22. Ronco, A. L., and Fernandez, R., Improving ultrasonographic diagnosis of prostate cancer with neural networks. Ultrasound Med. Biol. 25(5):729–733, 1999.

    Article  Google Scholar 

  23. Allahverdi, N., Expert systems. An artificial ıntelligence application. Atlas Press, Istanbul, 2002.

    Google Scholar 

  24. Türker, N., Tokan, F., and Yıldırım, T. Determination of artificial neural networks performances by roc analysis on the diagnosis of heart disease. Biomedical Engineering National Congres, BİYOMUT 2005, İstanbul 206–208, 2005.

  25. Wichard, J.D., Cammann, H., Stephan, C., and Tolxdorff, T. Classification models for early detection of prostate cancer. Hindawi Publishing Corporation Journal of Biomedicine and Biotechnology 7, 2008.

Download references

Acknowledgements

This study was supported by Selcuk University Coordination Office of Scientific Research Projects (BAP). Moreover, I would like to express my heartfelt thanks for Prof. Dr. Unal SERT of Selcuk University, Meram Medicine Faculty, who was my advisor and helped me in the evaluation of breast cancer data.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Ismail Saritas.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Saritas, I. Prediction of Breast Cancer Using Artificial Neural Networks. J Med Syst 36, 2901–2907 (2012). https://doi.org/10.1007/s10916-011-9768-0

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10916-011-9768-0

Keywords

Navigation