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High salt and fat intake, inflammation, and risk of cancer

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Frontiers in Biology

Abstract

Background

Inflammatory conditions are involved in the pathophysiology of cancer. Recent findings have revealed that excessive salt and fat intake is involved in the development of severe inflammatory reactions.

Methods

literature search was performed on various online databases (PubMed, Scopus, and Google Scholar) regarding the roles of high salt and fat intake in the induction of inflammatory reactions and their roles in the etiopathogenesis of cancer.

Results

The results indicate that high salt and fat intake can induce severe inflammatory conditions. However, various inflammatory conditions have been strongly linked to the development of cancer. Hence, high salt and fat intake might be involved in the pathogenesis of cancer progression via putative mechanisms related to inflammatory reactions.

Conclusion

Reducing salt and fat intake may decrease the risk of cancer.

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References

  • Alizadeh D, Katsanis E, Larmonier N (2013). The multifaceted role of Th17 lymphocytes and their associated cytokines in cancer. Clin Dev Immunol, 2013: 957878

    Article  PubMed  PubMed Central  Google Scholar 

  • Amara S, Alotaibi D, Tiriveedhi V (2016). NFAT5/STAT3 interaction mediates synergism of high salt with IL-17 towards induction of VEGF-A expression in breast cancer cells. Oncol Lett, 12(2): 933–943

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Amara S, Ivy M T, Myles E L, Tiriveedhi V (2016). Sodium channel ENaC mediates IL-17 synergized high salt induced inflammatory stress in breast cancer cells. Cell Mmunol, 302: 1–10

    Article  CAS  Google Scholar 

  • Barbaresko J, Koch M, Schulze M B, Nöthlings U (2013). Dietary pattern analysis and biomarkers of low-grade inflammation: a systematic literature review. Nutr Rev, 71(8): 511–527

    Article  PubMed  Google Scholar 

  • Binger K J, Gebhardt M, Heinig M, Rintisch C, Schroeder A, Neuhofer W, Hilgers K, Manzel A, Schwartz C, Kleinewietfeld M, Voelkl J, Schatz V, Linker R A, Lang F, Voehringer D, Wright MD, Hubner N, Dechend R, Jantsch J, Titze J, Müller D N (2015). High salt reduces the activation of IL-4-and IL-13-stimulated macrophages. J Clin Invest, 125(11): 4223–4238

    Article  PubMed  PubMed Central  Google Scholar 

  • Binger K J, Linker R A, Muller D N, Kleinewietfeld M (2015). Sodium chloride, SGK1, and Th17 activation. Pflugers Arch, 467(3): 543–550

    Article  CAS  PubMed  Google Scholar 

  • Catta-Preta M, Martins, M A, Cunha Brunini TM, Mendes-Ribeiro A C, Mandarim-de-Lacerda C A, Aguila M B (2012). Modulation of cytokines, resistin, and distribution of adipose tissue in C57BL/6 mice by different high-fat diets. Nutrition, 28(2): 212–219

    Article  CAS  PubMed  Google Scholar 

  • Cho H J, Kwon G T, Park H, Song H, Lee KW, Kim J I, Park J H (2015). A high-fat diet containing lard accelerates prostate cancer progression and reduces survival rate in mice: possible contribution of adipose tissue-derived cytokines. Nutrients, 7(4): 2539–2561

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Coussens L M, Werb Z (2002). Inflammation and cancer. Nature, 420 (6917): 860–867

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Cowen S, McLaughlin S L, Hobbs G, Coad J, Martin K H, Olfert I M, Vona-Davis L (2015). High-fat, high-calorie diet enhances mammary carcinogenesis and local inflammation in MMTV-PyMT mouse model of breast cancer. Cancers (Basel), 7(3): 1125–1142

    Article  CAS  Google Scholar 

  • D’Elia L, Rossi G, Ippolito R, Cappuccio F P, Strazzullo P (2012). Habitual salt intake and risk of gastric cancer: a meta-analysis of prospective studies. Clin Nutr, 31(4): 489–498

    Article  PubMed  Google Scholar 

  • Dutheil S, Ota K T, Wohleb E S, Rasmussen K, Duman R S (2016). High-Fat Diet Induced Anxiety and Anhedonia: Impact on Brain Homeostasis and Inflammation. Neuropsychopharmacology, 41(7): 1874–1887 (Original Article)

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Eichelmann F, Schwingshackl L, Fedirko V, Aleksandrova K (2016). Effect of plant-based diets on obesity-related inflammatory profiles: a systematic review and meta-analysis of intervention trials. Obes Rev, 17(11): 1067–1079

    Article  CAS  PubMed  Google Scholar 

  • Faeh D, Rohrmann S, Puhan M, Braun J (2014). Added salt and cancer mortality: confounding by smoking. Epidemiology, 25(4): 615–616

    Article  PubMed  Google Scholar 

  • Farez M F, Fiol M P, Gaitán M I, Quintana F J, Correale J (2015). Sodium intake is associated with increased disease activity in multiple sclerosis. J Neurol Neurosurg Psychiatry, 86(1): 26–31

    Article  PubMed  Google Scholar 

  • Fox J G, Dangler C A, Taylor N S, King A, Koh T J, Wang T C (1999). High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res, 59(19): 4823–4828

    CAS  PubMed  Google Scholar 

  • Gaddy J A, Radin J N, Loh J T, Zhang F, Washington MK, Peek RM Jr, Algood H M, Cover T L (2013). High dietary salt intake exacerbates Helicobacter pylori-induced gastric carcinogenesis. Infect Immun,81(6): 2258–2267

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Grivennikov S I, Greten F R, Karin M (2010). Immunity, inflammation, and cancer. Cell, 140(6): 883–899

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Guéry L, Hugues S (2015). Th17 cell plasticity and functions in cancer immunity. Biomed Res Int, 2015: 314620

    Article  PubMed  PubMed Central  Google Scholar 

  • Gulhane M, Murray L, Lourie R, Tong H, Sheng Y H, Wang R, Kang A, Schreiber V, Wong K Y, Magor G, Denman S, Begun J, Florin T H, Perkins A, Cuív P Ó, McGuckin M A, Hasnain S Z (2016). High fat diets induce colonic epithelial cell stress and inflammation that is reversed by IL-22. Sci Rep, 6: 28990

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Han J, Jiang Y, Liu X, Meng Q, Xi Q, Zhuang Q, Han Y, Gao Y, Ding Q, Wu G (2015). Dietary fat intake and risk of gastric cancer: a metaanalysis of observational studies. PLoS One, 10(9): e0138580

    Article  PubMed  PubMed Central  Google Scholar 

  • Hemdan N Y (2013). Anti-cancer versus cancer-promoting effects of the interleukin-17-producing T helper cells. Immunol Lett, 149(1-2): 123–133

    Article  CAS  PubMed  Google Scholar 

  • Hernandez A L, Kitz A, Wu C, Lowther D E, Rodriguez D M, Vudattu N, Deng S, Herold K C, Kuchroo V K, Kleinewietfeld M, Hafler D A (2015). Sodium chloride inhibits the suppressive function of FOXP3 + regulatory T cells. J Clin Invest, 125(11): 4212–4222

    Article  PubMed  PubMed Central  Google Scholar 

  • Howe L R, Subbaramaiah K, Hudis C A, Dannenberg A J (2013). Molecular pathways: adipose inflammation as a mediator of obesityassociated cancer. Clin Cancer Res, 19(22): 6074–6083

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Hucke S, Eschborn M, Liebmann M, Herold M, Freise N, Engbers A, Ehling P, Meuth S G, Roth J, Kuhlmann T, Wiendl H, Klotz L (2016). Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity. J Autoimmun, 67: 90–101

    Article  CAS  PubMed  Google Scholar 

  • Jhun J Y, Yoon B Y, Park M K, Oh H J, Byun J K, Lee S Y, Min J K, Park S H, Kim H Y, Cho M L (2012). Obesity aggravates the joint inflammation in a collagen-induced arthritis model through deviation to Th17 differentiation. Exp Mol Med, 44(7): 424–431

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Jörg S, Kissel J, Manzel A, Kleinewietfeld M, Haghikia A, Gold R, Müller D N, Linker R A (2016). High salt drives Th17 responses in experimental autoimmune encephalomyelitis without impacting myeloid dendritic cells. Exp Neurol, 279: 212–222

    Article  PubMed  Google Scholar 

  • Kato S, Tsukamoto T, Mizoshita T, Tanaka H, Kumagai T, Ota H, Katsuyama T, Asaka M, Tatematsu M (2006). High salt diets dosedependently promote gastric chemical carcinogenesis in Helicobacter pylori-infected Mongolian gerbils associated with a shift in mucin production from glandular to surface mucous cells. Int J Cancer, 119 (7): 1558–1566

    Article  CAS  PubMed  Google Scholar 

  • Kim I H, Xu J, Liu X, Koyama Y, Ma H Y, Diggle K, You Y H, Schilling J M, Jeste D, Sharma K, Brenner D A, Kisseleva T (2016). Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice. Age (Dordr), 38(4): 291–302 (journal article)

    Article  CAS  Google Scholar 

  • Kleinewietfeld M, Manzel A, Titze J, Kvakan H, Yosef N, Linker R A, Muller D N, Hafler D A (2013). Sodium chloride drives autoimmune disease by the induction of pathogenic TH17 cells. Nature, 496 (7446): 518–522

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kotchen T A, Cowley A W Jr, Frohlich E D (2013). Salt in health and disease–a delicate balance. N Engl J Med, 368(13): 1229–1237

    Article  CAS  PubMed  Google Scholar 

  • Krementsov D N, Case L K, Hickey W F, Teuscher C (2015). Exacerbation of autoimmune neuroinflammation by dietary sodium is genetically controlled and sex specific. FASEB J, 29(8): 3446–3457

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Kroenke C H, Kwan M L, Sweeney C, Castillo A, Caan B J (2013). High- and low-fat dairy intake, recurrence, and mortality after breast cancer diagnosis. J Natl Cancer Inst, 105(9): 616–623

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lin W W, Karin M (2007). A cytokine-mediated link between innate immunity, inflammation, and cancer. J Clin Invest, 117(5): 1175–1183

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Lippitz B E (2013). Cytokine patterns in patients with cancer: a systematic review. Lancet Oncol, 14(6): e218–e228

    Article  CAS  PubMed  Google Scholar 

  • Loh J T, Gaddy J A, Algood H M S, Gaudieri S, Mallal S, Cover T L (2015). Helicobacter pylori adaptation in vivo in response to a highsalt diet. Infect Immun, 83(12): 4871–4883

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Manzel A, Muller D N, Hafler D A, Erdman S E, Linker R A, Kleinewietfeld M (2014). Role of “Western diet” in inflammatory autoimmune diseases. Curr Allergy Asthma Rep, 14(1): 404

    Article  PubMed  PubMed Central  Google Scholar 

  • Monteleone I, Marafini I, Dinallo V, Di Fusco D, Troncone E, Zorzi F, et al (2017). Sodium chloride-enriched diet enhances inflammatory cytokine production and exacerbates experimental colitis in mice. J Crohn’s Colitis, 11(2):237–245

    Article  Google Scholar 

  • Mozaffarian D, Fahimi S, Singh GM, Micha R, Khatibzadeh S, Engell R E, Lim S, Danaei G, Ezzati M, Powles J, the Global Burden of Diseases Nutrition and Chronic Diseases Expert Group (2014). Global sodium consumption and death from cardiovascular causes. N Engl J Med, 371(7): 624–634

    Article  PubMed  Google Scholar 

  • Nagini S (2012). Carcinoma of the stomach: A review of epidemiology, pathogenesis, molecular genetics and chemoprevention. World J Gastrointest Oncol, 4(7): 156–169

    Article  PubMed  PubMed Central  Google Scholar 

  • Nozaki K, Shimizu N, Inada K, Tsukamoto T, Inoue M, Kumagai T, Sugiyama A, Mizoshita T, Kaminishi M, Tatematsu M (2002). Synergistic promoting effects of Helicobacter pylori infection and high-salt diet on gastric carcinogenesis in Mongolian gerbils. Jpn J Cancer Res, 93(10): 1083–1089

    Article  CAS  PubMed  Google Scholar 

  • Okada Y, Tsuzuki Y, Sato H, Narimatsu K, Hokari R, Kurihara C, Watanabe C, Tomita K, Komoto S, Kawaguchi A, Nagao S, Miura S (2013). Trans fatty acids exacerbate dextran sodium sulphate-induced colitis by promoting the up-regulation of macrophage-derived proinflammatory cytokines involved in T helper 17 cell polarization. Clin Exp Immunol, 174(3): 459–471

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Paik J, Fierce Y, Treuting P M, Brabb T, Maggio-Price L (2013). Highfat diet-induced obesity exacerbates inflammatory bowel disease in genetically susceptible Mdr1a-/- male mice. J Nutr, 143(8): 1240–1247

    Article  CAS  PubMed  Google Scholar 

  • Reddy B S, Maeura Y (1984). Tumor promotion by dietary fat in azoxymethane-induced colon carcinogenesis in female F344 rats: influence of amount and source of dietary fat. J Natl Cancer Inst, 72 (3): 745–750

    CAS  PubMed  Google Scholar 

  • Richman E L, Kenfield S A, Chavarro J E, Stampfer MJ, Giovannucci E L, Willett W C, Chan J M (2013). Fat intake after diagnosis and risk of lethal prostate cancer and all-cause mortality. JAMA Intern Med, 173(14): 1318–1326

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Schwingshackl L, Hoffmann G (2014). Adherence to Mediterranean diet and risk of cancer: a systematic review and meta-analysis of observational studies. Int J Cancer, 135(8): 1884–1897

    Article  CAS  PubMed  Google Scholar 

  • Schwingshackl L, Hoffmann G (2014). Mediterranean dietary pattern, inflammation and endothelial function: a systematic review and meta-analysis of intervention trials. Nutr Metab Cardiovasc Dis, 24(9): 929–939

    Article  CAS  PubMed  Google Scholar 

  • Teodoro J S, Varela A T, Rolo A P, Palmeira C M (2014). High-fat and obesogenic diets: current and future strategies to fight obesity and diabetes. Genes Nutr, 9(4): 406

    Article  PubMed  PubMed Central  Google Scholar 

  • Timmermans S, Bogie J F J, Vanmierlo T, Lütjohann D, Stinissen P, Hellings N, Hendriks J J (2014). High fat diet exacerbates neuroinflammation in an animal model of multiple sclerosis by activation of the Renin Angiotensin system. J Neuroimmune Pharmacol, 9(2): 209–217 (journal article)

    Article  PubMed  Google Scholar 

  • Wang D D, Li Y, Chiuve S E, Stampfer M J, Manson J E, Rimm E B, Willett W C, Hu F B (2016). Association of specific dietary fats with total and cause-specific mortality. JAMA Intern Med, 176(8): 1134–1145

    Article  PubMed  PubMed Central  Google Scholar 

  • Wicki A, Hagmann J (2011). Diet and cancer. Swiss Med Wkly, 141: w13250

    CAS  Google Scholar 

  • Wu C, Yosef N, Thalhamer T, Zhu C, Xiao S, Kishi Y, Regev A, Kuchroo V K (2013). Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1. Nature, 496(7446): 513–517

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  • Xu Y, Yan Y, Hou M X, Liu Y E (2015). NaCl pretreatment attenuates H.pylori-induced DNA damage and exacerbates proliferation of gastric epithelial cells (GES-1). Infect Agent Cancer, 10(1): 8

    Article  PubMed  PubMed Central  Google Scholar 

  • Yi B, Titze J, Rykova M, Feuerecker M, Vassilieva G, Nichiporuk I, Schelling G, Morukov B, Choukèr A (2015). Effects of dietary salt levels on monocytic cells and immune responses in healthy human subjects: a longitudinal study. Transl Res, 166(1): 103–110

    Article  CAS  PubMed  Google Scholar 

  • Yusof A S, Isa Z M, Shah S A (2012). Dietary patterns and risk of colorectal cancer: a systematic review of cohort studies (2000-2011). Asian Pac J Cancer Prev, 13(9): 4713–4717

    Article  PubMed  Google Scholar 

  • Zhang T, Fang S, Wan C, Kong Q, Wang G, Wang S, Zhang H, Zou H, Sun B, Sun W, Zhang Y, Mu L, Wang J, Wang J, Zhang H, Wang D, Li H (2015). Excess salt exacerbates blood-brain barrier disruption via a p38/MAPK/SGK1-dependent pathway in permanent cerebral ischemia. Scientific Rep, 5: 16548

    Article  CAS  Google Scholar 

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Correspondence to Amir Abdoli.

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Abdoli, A. High salt and fat intake, inflammation, and risk of cancer. Front. Biol. 12, 387–391 (2017). https://doi.org/10.1007/s11515-017-1471-1

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