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RNA-binding proteins in pluripotency, differentiation, and reprogramming

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Frontiers in Biology

Abstract

Embryonic stem cell maintenance, differentiation, and somatic cell reprogramming require the interplay of multiple pluripotency factors, epigenetic remodelers, and extracellular signaling pathways. RNA-binding proteins (RBPs) are involved in a wide range of regulatory pathways, from RNA metabolism to epigenetic modifications. In recent years we have witnessed more and more studies on the discovery of new RBPs and the assessment of their functions in a variety of biological systems, including stem cells. We review the current studies on RBPs and focus on those that have functional implications in pluripotency, differentiation, and/or reprogramming in both the human and mouse systems.

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  1. The Black Family Stem Cell Institute, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Diana Guallar & Jianlong Wang

  2. Department of Developmental and Regenerative Biology, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Diana Guallar & Jianlong Wang

  3. The Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, 10029, USA

    Jianlong Wang

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Guallar, D., Wang, J. RNA-binding proteins in pluripotency, differentiation, and reprogramming. Front. Biol. 9, 389–409 (2014). https://doi.org/10.1007/s11515-014-1326-y

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