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Utility of Localized Surface Plasmon Resonance of Gold Nanoparticles for Spectrophotometric Determination of Dobutamine in Pharmaceutical Formulations

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Abstract

Dobutamine is a frequently employed β-adrenergic receptor agonist that is utilized to provide cardiac hemodynamic support and for stress testing in echocardiography. This study introduces a spectrophotometric method for quantifying dobutamine by utilizing the localized surface plasmon resonance (SPR) characteristic of gold nanoparticles. A band of SPR is generated through the reduction of gold ions using dobutamine as a reducing agent. Experiment optimization was achieved by investigating the effects of the reaction variables, such as the formation time of the produced gold nanoparticles, volume of reagent, and volume stabilizer. Transmission electron microscopic and scanning electron microscopic analyses were conducted to verify and identify the formation of gold nanoparticles. Furthermore, the formed nanoparticles were characterized by the dynamic light scattering (zetasizer) technique. The proposed approach underwent validation in accordance with the ICH recommendations. In the best conditions, the statistical analysis showed that the absorbance of gold nanoparticles at 525 nm was directly linked to the concentration of dobutamine in the range of 0.5 to 2.0 µg/mL, with a detection limit of 0.072 µg/mL. The suggested colorimetric assay demonstrates good repeatability and accuracy, offering a straightforward and expeditious approach to analyzing dobutamine. In addition, the developed method was successfully utilized for determining dobutamine in pharmaceutical ampoule samples.

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The data used and/or analyzed in the current study are provided in the submitted article.

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Acknowledgements

The authors extend their appreciation to the Researchers Supporting Project Number (RSPD2024R944), King Saud University, Riyadh, Saudi Arabia, for funding this research work.

Funding

The authors received funding from the King Saud University, Riyadh, Saudi Arabia, Researchers Supporting Project Number (RSPD2024R944) for this research work.

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Authors and Affiliations

  1. Department of Pharmaceutical Analytical Chemistry, Faculty of Pharmacy, Al-Azhar University, Assiut Branch, Assiut, 71524, Egypt

    Mohamed A. Abdel-Lateef

  2. School of Mechanical Engineering, Hebei University of Technology, Tianjin, 300401, China

    Hassanien Gomaa

  3. Department of Pharmaceutical Chemistry, College of Pharmacy, King Saud University, P.O. Box 2457, 11451, Riyadh, Saudi Arabia

    Ibrahim A. Darwish

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  1. Mohamed A. Abdel-Lateef
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Contributions

M.A., H.G. and I.D. wrote the main manuscript text and carried out the methodology, Writing - Review & Editing, Conceptualization, Investigation, Resources, Visualization, Data Curation, Validation, Supervision, Project administration.

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Correspondence to Mohamed A. Abdel-Lateef.

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Abdel-Lateef, M.A., Gomaa, H. & Darwish, I.A. Utility of Localized Surface Plasmon Resonance of Gold Nanoparticles for Spectrophotometric Determination of Dobutamine in Pharmaceutical Formulations. Plasmonics (2024). https://doi.org/10.1007/s11468-024-02331-3

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