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Utilization of unmodified gold nanoparticles in colorimetric detection

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  • Special Topic: Nanomaterials
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Abstract

This review begins with an overview of the appealing properties and various applications of gold nanoparticles, and briefly summarizes recent advances in using unmodified gold nanoparticles to detect different kinds of targets including nucleic acids, proteins, metal ions and small organic molecules. The key point to the unmodified gold nanoparticle-based visual detection assay is to control dispersion and aggregation of colloidal nanoparticles by targets of interest, which usually relies on affinities between gold nanoparticles and targets. The degree of dispersion or aggregation can be visualized through the change of the solution color or the precipitation of nanoparticles from the solution. Thus, the existence of the target molecules can be translated into optical signals and monitored by the naked eye conveniently. Finally, some future prospects of this research field are given.

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Authors and Affiliations

  1. College of Bioengineering, Chongqing University, Chongqing, 400044, China

    Sha He & KaiYong Cai

  2. National Center for NanoScience and Technology, Chinese Academy of Sciences Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, Beijing, 100190, China

    Sha He, DingBin Liu, Zhuo Wang & XingYu Jiang

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  1. Sha He
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  2. DingBin Liu
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  3. Zhuo Wang
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Correspondence to KaiYong Cai or XingYu Jiang.

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He, S., Liu, D., Wang, Z. et al. Utilization of unmodified gold nanoparticles in colorimetric detection. Sci. China Phys. Mech. Astron. 54, 1757 (2011). https://doi.org/10.1007/s11433-011-4486-7

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