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Bioassay studies of cobalt (II) complexes of modified diamine

  • Research Article
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Frontiers of Chemistry in China

Abstract

Coordination compounds of modified diamine, the basic unit of which are ethylenediamine, with that of Co (II) are prepared. The modified diamines are ethylenediaceticacid (EDDA) and N,N,N,N-tetaraethylene-1,2-diamine (TEEDA). These diamines are characterized through 1H-NMR, 13C-NMR, elemental analysis and IR techniques. Cobalt (II) complexes of these two ligands were prepared and characterized by physical measurements including elemental analysis, IR, UV-Visible, magnetic susceptibilities and conductance measurements. Antibacterial activities are also carried out in order to investigate the biological activity upon complexation. They were screened against four pathogenic bacteria like Escherichia coli, Pseudomonas aeroginosa, Klesbella pneumonia and Staphylococcus aureus. The results showed significant enhancement in activities.

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References

  1. Louie, A. Y.; Meade, T. J., Chem. Rev. 1999, 99, 2711–2734

    Article  CAS  Google Scholar 

  2. Scozzafava, A.; Menabuoni, L.; Mincione, F.; Mincione, G.; Supuran, C. T., Bioorg. Med. Chem. Lett. 2001, 11, 575–582

    Article  CAS  Google Scholar 

  3. Scozzafava, A.; Supran, C. T., Bioorg. Med. Chem. Lett. 2000, 43, 3577

    Google Scholar 

  4. Williams, R. J. P., Bioinorganic Chemistry, American Chemical Society, Washington, 1971

    Google Scholar 

  5. Brown, D. H.; Smith, W. E.; Teape, J. W.; Lewis, A. J., J. Med. Chem. 1980, 23, 729–734

    Article  CAS  Google Scholar 

  6. Gillard, R. D., Inorg. Chim. Acta Rev. 1961, 1, 60

    Google Scholar 

  7. Walsh, C., Science 2001, 409, 226

    CAS  Google Scholar 

  8. Bertini, I.; Gray, H. B.; Lippard, S. J.; Valentine, J. S., Bioinorganic Chemistry, University Science Books, Mill Valley, 1994

    Google Scholar 

  9. Kirchner, S.; Wei, Y. K.; Francis, D.; Bergman, J. G., J. Med. Chem. 1966, 9, 369–372

    Article  Google Scholar 

  10. Hussain, M. S. Rehman, S. U., Z. Naturforsch. 1978, 33b, 67

    CAS  Google Scholar 

  11. Hussain, M. S.; Rehman, S. U., Inorg. Chim. Acta 1982, 60, 233

    Article  Google Scholar 

  12. Sorenson, J. R. L., Inflammatory Diseases and Copper, Human Press, NJ, 1982

    Google Scholar 

  13. Nagar, R.; Mohan, G., J. Inorg. Biochem. 1991, 42, 9–16

    Article  CAS  Google Scholar 

  14. Oga, S.; Taniguchi, S. F.; Najjar, R.; Souza, A. R., J. Inorg. Biochem. 1991, 41, 45–51

    Article  CAS  Google Scholar 

  15. Barboiu, M.; Cimpoisu, M.; Guran, C.; Supran, C. T., Metal based Drugs 1996, 3, 227

    Article  CAS  Google Scholar 

  16. Hodgkin, D. G.; Pickworth, J.; Robertson, J. H.; Trueblood, K. N.; Prosen, R. J.; White, J. G., Nature 1955, 176, 325–328

    Article  CAS  Google Scholar 

  17. Barker, H. A.; Rooze, V.; Suzuki, F.; Iodice, A. A., J. Biol. Chem. 1964, 239, 3260–3266

    CAS  Google Scholar 

  18. Cannata, J. J. B.; Focesi, A. Jr; Mazumder, R.; Warner, R. C.; Ochoa, S., J. Biol. Chem. 1965, 240, 3249–3257

    CAS  Google Scholar 

  19. Flavin, M.; Ochoa, S., J. Biol. Chem. 1957, 229, 965–979

    CAS  Google Scholar 

  20. Kaziro, Y.; Ochoa, S., Adv. Enzymol. Relat. Areas Mol. Biol. 1964, 26, 283–378

    CAS  Google Scholar 

  21. Abeles, R. H.; Lee, H. A. Jr, J. Biol. Chem. 1961, 236, 2347–2350

    CAS  Google Scholar 

  22. Babior, B. M., J. Biol. Chem. 1969, 244, 2917–2926

    CAS  Google Scholar 

  23. Abrams, R.; Duraiswami, S., Biochem. Biophys. Res. Commun. 1965, 18, 409–414

    Article  CAS  Google Scholar 

  24. Burke, G. T.; Mangum, J. H.; Brodie, J. D., Biochemistry 1970, 9, 4297–4302

    Article  CAS  Google Scholar 

  25. Wood, J. M.; Kennedy, F. S.; Wolfe, R. S., J. Biol. Chem. 1968, 7, 1707

    CAS  Google Scholar 

  26. Ghambeer, R. K.; Wood, H. G.; Schulman, M.; Ljungdahl, L., Arch. Biochem. Biophys. 1971, 143, 471–484

    Article  CAS  Google Scholar 

  27. Rehman, S. U.; Noreen, S.; Rashida, M.; Ikram, K.; Ali, I.; Ahmad, M. A.; Bukhari, I. H., Nucleus 2009, 46, 501–506

    CAS  Google Scholar 

  28. Legg, J. I.; Averill, D. F.; Smith, D. L., Inorg. Chem. 1972, 11, 2344–2349

    Article  Google Scholar 

  29. Omar, M. M.; Mohamed, G. G.; Ibrahim, A. A., Spectrochim. Acta A Mol. Biomol. Spectrosc. 2009, 73, 358–369

    Article  CAS  Google Scholar 

  30. Musker, W. K.; Hussain, M. S., Inorg. Chem. 1966, 5, 1416–1419

    Article  CAS  Google Scholar 

  31. Musker, W. K.; Hussain, M. S., Inorg. Chem. 1969, 8, 528–536

    Article  CAS  Google Scholar 

  32. Figgis B. N., Lewis J., Wilkins R. G. (Eds), Modern Coordination Chemistry, New York: Interscience, 1960, 412

    Google Scholar 

  33. Vogel’s, A Text Book of Quantitative Inorganic Analysis, 4th Ed. London: ELBS and Longman, 1978

    Google Scholar 

  34. Atta-ur-Rahman, Choudhary, M. I.; Thomsen, W. J., Bioassay Techniques for Drug Development. Amsterdam: Harwood Academic, 2001

    Book  Google Scholar 

Download references

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Authors and Affiliations

  1. Institute of Chemical Sciences, University of Peshawar, Peshawar, 25120, Pakistan

    Saeed Ur-Rehman, Muhammad Ikram, Sadia Rehman & Shah Nawaz

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  1. Saeed Ur-Rehman
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  2. Muhammad Ikram
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  3. Sadia Rehman
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  4. Shah Nawaz
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Correspondence to Saeed Ur-Rehman.

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Ur-Rehman, S., Ikram, M., Rehman, S. et al. Bioassay studies of cobalt (II) complexes of modified diamine. Front. Chem. China 6, 98–104 (2011). https://doi.org/10.1007/s11458-011-0232-y

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  • DOI: https://doi.org/10.1007/s11458-011-0232-y

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