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Study on the interaction of aminoglycoside antibiotics with Titan Yellow by spectrophotometric method and their analytical applications

  • Research Article
  • Published:
Frontiers of Chemistry in China

Abstract

In a weak acidic medium, the reaction of some aminoglycoside antibiotics (AGs) such as kanamycin sulfate (KANA), gentamycin sulfate (GEN), and tobramycin sulfate (TOB) with acid thiazolyl bisazo dye Titan Yellow (TY) can result in the fading of TY. The maximum fading wavelength was located at 409 nm. The molar absorptivities (ɛ/×104 1 mol−1 cm−1) were 2.0, 1.5 and 2.5 for KANA, GEN and TOB, respectively. The spectral characteristics, effect factors, optimum conditions of the reaction and the influence of foreign substances were also investigated. The procedure is easy and fast. This method has high sensitivity and can be applied to the determination of commercial aminoglycoside antibiotics and serum samples with satisfactory results.

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Authors and Affiliations

  1. School of Chemistry and Chemical Engineering, Southwest China University, Chongoing, 400715, China

    Wang Mingxia, Liu Zhongfang, Hu Xiaoli, Liu Shaopu & Kong Ling

Authors
  1. Wang Mingxia
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  2. Liu Zhongfang
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  3. Hu Xiaoli
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  4. Liu Shaopu
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  5. Kong Ling
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Corresponding author

Correspondence to Liu Shaopu.

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Translated from Journal of southwest China Normal University, 2005, 30(2) (in Chinese)

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Wang, M., Liu, Z., Hu, X. et al. Study on the interaction of aminoglycoside antibiotics with Titan Yellow by spectrophotometric method and their analytical applications. Front. Chem. China 1, 170–173 (2006). https://doi.org/10.1007/s11458-006-0020-2

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  • DOI: https://doi.org/10.1007/s11458-006-0020-2

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