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One pot cascade synthesis of substituted 1,2,4-triazol-3-ones

  • Article
  • Organic Chemistry
  • Published:
Chinese Science Bulletin

Abstract

Substituted triazolinones were prepared by a three-component reaction of aldehydes, hydrazines and azodicarboxylates using TFA as a catalyst. The procedure was convenient and efficient, utilizing readily available substrates. A plausible mechanism for the cascade process is proposed.

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Authors and Affiliations

  1. Department of Chemistry, Zhejiang University, Hangzhou, 310027, China

    YeHua Su, Zhen Jiang, Deng Hong, XianFu Lin & YanGuang Wang

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  1. YeHua Su
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  2. Zhen Jiang
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  3. Deng Hong
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  4. XianFu Lin
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  5. YanGuang Wang
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Correspondence to YanGuang Wang.

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Su, Y., Jiang, Z., Hong, D. et al. One pot cascade synthesis of substituted 1,2,4-triazol-3-ones. Chin. Sci. Bull. 55, 2879–2884 (2010). https://doi.org/10.1007/s11434-010-4018-2

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  • DOI: https://doi.org/10.1007/s11434-010-4018-2

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