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Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes

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  • Special Topic: Asymmetric Organocatalysis
  • Published:
Chinese Science Bulletin

Abstract

Benzoin condensation is an important carbon-carbon bond-forming reaction. The benzoin reaction with good yield, high enantioselectivity and broad substrate scope is highly desired in organic synthesis. The intermolecular benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes has been investigated, and the corresponding α-hydroxyketones were obtained with yields up to 76% and enantioselectivities up to 99% ee.

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Authors and Affiliations

  1. Beijing National Laboratory for Molecular Sciences, CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing, 100190, China

    XueLiang Huang & Song Ye

Authors
  1. XueLiang Huang
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  2. Song Ye
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Correspondence to Song Ye.

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Huang, X., Ye, S. Enantioselective benzoin condensation catalyzed by bifunctional N-heterocyclic carbenes. Chin. Sci. Bull. 55, 1753–1757 (2010). https://doi.org/10.1007/s11434-010-3122-7

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  • DOI: https://doi.org/10.1007/s11434-010-3122-7

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