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Progress in fabricating arrays of soft spherical vessels on mesoscale with spatial control

  • Review/Polymer Chemistry
  • Published:
Chinese Science Bulletin

Abstract

Microarrays of spherical vessel-like colloids such as liposomes, polymerized vesicles and polyelectrolyte capsules may find diverse applications in bioanalysis, biosensing, and combinatorial chemistry, for their capabilities in encapsulating chemical species such as drugs, biomolecules, probes, polymers and nanoparticles. This review reports the advances on methods for fabricating microarrays of the various hollow colloids. Related strategies are described in detail, including patterning techniques, surface modification methods, and tethering approaches such as oligonucleotide hybridization, receptor-ligand binding, covalent coupling and electrostatic interaction. The preliminary developments of functionalities of these arrays serving as sensor chips, microcarriers and microreactors are summarized as well.

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Authors and Affiliations

  1. Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, China

    Jie Yang & ChangYou Gao

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  1. Jie Yang
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  2. ChangYou Gao
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Correspondence to ChangYou Gao.

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Supported by the Postdoc Foundation of Zhejiang Province, the National Natural Science Foundation of China (Grant Nos. 20434030, 20774084), the National Basic Research Program of China (Grant No. 2005CB623902) and the National Natural Science Funds for Distinguished Young Scholars of China (Grant No. 50425311)

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Yang, J., Gao, C. Progress in fabricating arrays of soft spherical vessels on mesoscale with spatial control. Chin. Sci. Bull. 53, 3477–3490 (2008). https://doi.org/10.1007/s11434-008-0485-0

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