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Tyramine-enhanced zwitterion hyaluronan hydrogel coating for anti-fouling and anti-thrombosis

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Abstract

Zwitterions have aroused much interest to endow implantable medical devices with anti-fouling and anti-thrombosis performance, due to their ability to form a hydrated layer that can provide a good barrier against protein and cell adhesion. Herein, tyramine modified sulfobetaine-derived sodium hyaluronan (HST) hydrogel coating was fabricated, in which hyaluronan (HA) was used as polysaccharide skeleton to graft zwitterionic sulfobetaine, and tyramine was introduced as crosslinker to construct both the network of hydrogel and a strong covalent bond between coating and substrate. Hydrogel coating was prepared by spin coating or painting HST prepolymer solution under ultraviolet light irradiation. The obtained HST hydrogel coating shows good stability. Moreover, in addition to its outstanding anti-fouling performance and good biocompatibility, it can effectively prevent thrombosis in blood circulation ex vivo. This work offers a universal strategy to prepare a high-performance anti-fouling and anti-thrombosis coating, which is expected to promote the development of functional coatings for biomedical materials.

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Authors and Affiliations

  1. School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300350, China

    ZhiCheng Guo, MengMeng Yao, MingYue Shi, XiaoRu Dong, ShaoShuai He, BingYan Guo, FangLian Yao, Hong Zhang & JunJie Li

  2. School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, 063210, China

    Hong Sun

  3. Frontiers Science Center for Synthetic Biology and Key Laboratory of Systems Bioengineering (Ministry of Education), Tianjin University, Tianjin, 300350, China

    FangLian Yao, Hong Zhang & JunJie Li

  4. School of Materials Science and Engineering, East China Jiaotong University, Nanchang, 330013, China

    FangLian Yao

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  1. ZhiCheng Guo
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  2. MengMeng Yao
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  3. Hong Sun
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  4. MingYue Shi
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  8. FangLian Yao
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  9. Hong Zhang
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  10. JunJie Li
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Corresponding authors

Correspondence to FangLian Yao, Hong Zhang or JunJie Li.

Additional information

This work was supported by the National Key Research and Development Program of China (Grant No. 2018YFC1105500), the National Natural Science Foundation of China (Grant Nos. U20A20261, 31870948, 31971250, and 52073205), and the Natural Science Foundation of Tianjin (Grant Nos. 20JCYBJC00660 and 21JCYBJC00560).

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Guo, Z., Yao, M., Sun, H. et al. Tyramine-enhanced zwitterion hyaluronan hydrogel coating for anti-fouling and anti-thrombosis. Sci. China Technol. Sci. 65, 1828–1844 (2022). https://doi.org/10.1007/s11431-022-2048-1

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