Abstract
Alteration in the Th17/Treg cell balance is implicated in various autoimmune diseases and these disease-associated pathologies. Increasing investigations have shown that glutamine metabolism regulates the differentiation of Th17 and Treg cells. Here we summarize the mechanisms by which glutamine metabolism regulates Th17/Treg cell fate. Some examples of a glutamine metabolism-dependent modulation of the development and progression of several Th17 Treg cell-associated diseases are provided afterward. This review will provide a comprehensive understanding of the importance of glutamine metabolism in the fate of Th17 Treg cell differentiation.
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Acknowledgements
Our profound admiration and respect go to researchers in this field and our laboratories, for their dedication and hard work. We apologize to scientists whose work is in this field if their papers are not cited owing to space limitations. This study was supported by the National Natural Science Foundation of China (31922079, 31872365, and 31790411) and Guangdong Basic and Applied Basic Research Foundation (2019B1515210002).
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Yang, G., Xia, Y. & Ren, W. Glutamine metabolism in Th17/Treg cell fate: applications in Th17 cell-associated diseases. Sci. China Life Sci. 64, 221–233 (2021). https://doi.org/10.1007/s11427-020-1703-2
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DOI: https://doi.org/10.1007/s11427-020-1703-2