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Advancement in regional immunity and its clinical implication

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Abstract

Organs in our body have formed their own unique immune surveillance system that is finely tuned by in situ milieu. Sequestrated tissue-resident immune cells differ from their counterparts in circulation and participate in tissue physiological activities and the maintenance of local homeostasis. Dysregulation of regional immunity leads to organ-specific inflammatory injuries. Here we review the recent developments in the field of tissue-resident immune cells and organ-specific regional immunity, and discuss their clinical implication.

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Acknowledgements

This work was supported by grants from the National Natural Science Foundation of China (81788104, 81630044, 81601432, 81550023, 81771763), the National Science Fund for Distinguished Young Scholars of China (81325019), National Key Research and Development Program: “Precise Medical Research” (2016YFC0903900), and Chinese Academy of Medical Science Innovation Fund for Medical Sciences (CIFM2016-12M-1-003, 2017-12M-1-008, 2016-12M-1-008), and 2016 Peking Union Medical College Hospital Fund for Junior Faculty (pumch-2016-2.1).

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  1. Department of Rheumatology and Clinical Immunology, Peking Union Medical College Hospital, Clinical Immunology Center, Chinese Academy of Medical Sciences and Peking Union Medical College, Ministry of Education Key Laboratory, Beijing, 100730, China

    Chen Zhou, Luxi Sun, Lidan Zhao & Xuan Zhang

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  1. Chen Zhou
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  2. Luxi Sun
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  3. Lidan Zhao
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Correspondence to Lidan Zhao or Xuan Zhang.

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Zhou, C., Sun, L., Zhao, L. et al. Advancement in regional immunity and its clinical implication. Sci. China Life Sci. 60, 1178–1190 (2017). https://doi.org/10.1007/s11427-017-9224-6

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