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Hydrophobic modification of polysaccharides and the construction and properties of their micelles: a review of applications in the field of biomedicine

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Abstract

Nanomedicine delivery technology plays an important role in modern medicine and has shown good therapeutic effects in scientific research. Polysaccharides have the characteristics of wide sources, excellent biocompatibility, and non-toxicity. In addition, there are multifunctional groups on the main chain of polysaccharides, which can be surface-modified or functionalized to have targeting ability through specific sugar parts. Amphiphilic polysaccharide micelles with good biocompatibility, degradability, high safety, easy structural modification, and special core-shell structure are regarded as ideal carriers for nanomedicines. Therefore, this review is focused on the hydrophobic modification designs of polysaccharides, the preparation methods and characteristics of micelles, and the applications of amphiphilic polysaccharide micelles in the field of biomedicine. It is expected to provide some ideas and inspiration for the design of polysaccharide drug carriers.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21874078, 22074072, 22274083), the Shandong Provincial Natural Science Foundation (ZR2022LZY022, ZR2023LZY005), the Science and Technology Planing Project of South District of Qingdao City (2022-4-005-YY), the Exploration project of the State Key Laboratory of BioFibers and EcoTextiles of Qingdao University (TSKT202101) and the High Level Discipline Project of Shandong Province.

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Authors and Affiliations

  1. College of Chemistry and Chemical Engineering, College of Life Sciences, College of Materials Science and Engineering, Institute of Biomedical Materials and Engineering, Qingdao University, Qingdao, 266071, China

    Dayang Wang, Xiaohua Li, Huanchen Yao, Xin Liu, Yan Gao, Hailin Cong, Bing Yu & Youqing Shen

  2. State Key Laboratory of Bio-Fibers and Eco-Textiles, Qingdao University, Qingdao, 266071, China

    Hailin Cong & Bing Yu

  3. School of Materials Science and Engineering, Shandong University of Technology, Zibo, 255000, China

    Hailin Cong

  4. Key Laboratory of Biomass Chemical Engineering of Ministry of Education, Center for Bionanoengineering, and Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou, 310027, China

    Youqing Shen

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  1. Dayang Wang
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  2. Xiaohua Li
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  3. Huanchen Yao
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  4. Xin Liu
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  5. Yan Gao
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  6. Hailin Cong
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  7. Bing Yu
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  8. Youqing Shen
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Correspondence to Hailin Cong or Bing Yu.

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Wang, D., Li, X., Yao, H. et al. Hydrophobic modification of polysaccharides and the construction and properties of their micelles: a review of applications in the field of biomedicine. Sci. China Chem. 67, 1881–1903 (2024). https://doi.org/10.1007/s11426-023-1916-5

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  • DOI: https://doi.org/10.1007/s11426-023-1916-5

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