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Electrochemical borylation of nitroarenes

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Abstract

A simple electrochemically mediated method for the conversion of nitroarenes to aryl boronic esters is presented. Electrochemical borylation of a diverse range of nitroarenes, including the late-stage borylation of bioactive molecules, is furnished at room temperature under simple conditions, thereby demonstrating the broad utility and functional-group tolerance of this protocol. This transformation provides a convenient and practical access to aryl boronic esters from widely available nitroarenes, which would significantly streamline the synthetic process of diverse functionalized arenes.

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Acknowledgements

This work was supported by the National Natural Science Foundation of China (21602096).

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Authors and Affiliations

  1. Key Laboratory of Catalysis and Energy Materials Chemistry of Ministry of Education & Hubei Key Laboratory of Catalysis and Materials Science, School of Chemistry and Materials Science, South-Central Minzu University, Wuhan, 430074, China

    Linlin Du & Hua Zhang

  2. School of Chemistry and Chemical Engineering, Nanchang University, Nanchang, 330031, China

    Linlin Du, Binfeng Zhang, Shuohan Ji, Hu Cai & Hua Zhang

Authors
  1. Linlin Du
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  2. Binfeng Zhang
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  3. Shuohan Ji
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  4. Hu Cai
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  5. Hua Zhang
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Correspondence to Hu Cai or Hua Zhang.

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Conflict of interest The authors declare no conflict of interest.

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Supporting information The supporting information is available online at http://chem.scichina.com and http://link.springer.com/journal/11426. The supporting materials are published as submitted, without typesetting or editing. The responsibility for scientific accuracy and content remains entirely with the authors.

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Du, L., Zhang, B., Ji, S. et al. Electrochemical borylation of nitroarenes. Sci. China Chem. 66, 534–539 (2023). https://doi.org/10.1007/s11426-022-1470-8

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